GRM2 and GRASP

Number of citations of the paper that reports this interaction (PMID 11850456)
30

Data Source:
HPRD (two hybrid)

		GRM2	GRASP
Gene Name		glutamate receptor, metabotropic 2	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Presynaptic Membrane	Cell Junction Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity	PDZ Domain Binding ADP-ribosylation Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic	Signal Transduction Protein Localization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Acamprosate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GNA15 GNAQ GRASP NAALADL2 RGS12 UBQLN1	7 interactors: CYTH3 DLG4 GABBR2 GRM1 GRM2 GRM3 GRM5
Entrez ID		2912	160622
HPRD ID		04977	17077
Ensembl ID		ENSG00000164082	ENSG00000161835
Uniprot IDs		Q14416 Q86YG3	Q7Z6J2
PDB IDs			2PNT
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Hydrolase Activity Cellular Response To Stimulus Neuron Remodeling Positive Regulation Of Catalytic Activity Regulation Of Melanocyte Differentiation G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Hemostasis Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Neuron Maturation Cell Activation Forebrain Neuron Development Response To Wounding Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Signal Transduction Regulation Of GTPase Activity Regulation Of Cellular Response To Oxidative Stress Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signaling Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Developmental Pigmentation Termination Of Signal Transduction	G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Nucleotide Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Locomotory Behavior Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Behavior Positive Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Learning G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Synaptic Plasticity Signaling Cell Communication Negative Regulation Of Catalytic Activity Cytosolic Calcium Ion Homeostasis Establishment Or Maintenance Of Cell Polarity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Negative Regulation Of Cellular Metabolic Process Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants
Tagcloud (Intersection) ?