GRM2 and TMEM130

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRM2	TMEM130
Description		glutamate metabotropic receptor 2	transmembrane protein 130
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		LY2140023
Diseases
GWAS			Decreased low contrast letter acuity in multiple sclerosis ( 31289819)
Interacting Genes		31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	10 interacting genes: GRM2 NKG7 OLFM4 PIGF SLC2A5 SLC35B4 SLC61A1 TMEM100 TSPAN2 YIPF6
Entrez ID		2912	222865
HPRD ID		04977	13226
Ensembl ID		ENSG00000164082	ENSG00000166448
Uniprot IDs		H7BXL3 Q14416	Q8N3G9
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Fructose Import Across Plasma Membrane UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Organic Anion Transport Group II Metabotropic Glutamate Receptor Activity Membrane Ethanolaminephosphotransferase Activity Microglia Development UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport
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