PYCARD and CASP1

Number of citations of the paper that reports this interaction (PMID 12191486)
502

Data Source:
HPRD (in vitro, in vivo)

		PYCARD	CASP1
Gene Name		PYD and CARD domain containing	caspase 1, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Extracellular Region Cytoplasm Cytosol IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protease Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyrin Domain Binding Protein Homodimerization Activity Ion Channel Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Rac GTPase Activity Interleukin-1 Beta Production Negative Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Chemokine Secretion Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Autophagy Response To Lipopolysaccharide Interleukin-1 Beta Production Response To ATP Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Mitochondrial Depolarization Membrane Hyperpolarization Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Execution Phase Of Apoptosis Programmed Necrotic Cell Death Toxin Transport
Pathways		The NLRP3 inflammasome Inflammasomes The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Signaling by Interleukins The NLRP3 inflammasome Inflammasomes NOD1/2 Signaling Pathway The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Interleukin-1 processing The IPAF inflammasome Cytokine Signaling in Immune system Innate Immune System
Drugs			Minocycline 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF	42 interactors: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP4 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARK2 PARP1 PLA2G4A PLA2G4B PSEN1 PSEN2 PYCARD RIPK2 TFAP2A TIRAP VAC14
Entrez ID		29108	834
HPRD ID		06020	00977
Ensembl ID		ENSG00000103490	ENSG00000137752
Uniprot IDs		Q9ULZ3	A8K249 A8K257 P29466
PDB IDs		1UCP 2KN6	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cytokine Secretion Regulation Of Endopeptidase Activity Regulation Of Protein Secretion Immune System Process Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Interleukin-1 Beta Production Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Cytokine Production Positive Regulation Of Hydrolase Activity Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion Positive Regulation Of Protein Transport Immune Response Positive Regulation Of Cytokine Production Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity	Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Response To Stress Immune Response Signaling Regulation Of Signaling Cell Communication Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteolysis Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Cell Death Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Localization Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Immune System Process Signal Transduction Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammation initiate lean mhcii nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 investigative joint neutralization osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?		inflammasome nlrp3