PYCARD and USP50

Number of citations of the paper that reports this interaction (PubMedID 37647255)
75

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PYCARD	USP50
Description		PYD and CARD domain containing	ubiquitin specific peptidase 50
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule IkappaB Kinase Complex Membrane Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex NLRP6 Inflammasome Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Postsynaptic Density Midbody
	Molecular Function	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Myosin I Binding Enzyme Binding Pyrin Domain Binding Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activator Activity	Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Response To Bacterium Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Macropinocytosis NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Pyroptotic Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Nuclear Speck Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Cycle G2/M Phase Transition
Pathways		CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245)	Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Myeloid white cell count ( 27863252) QT interval ( 24952745) Refractive error ( 32231278) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		15 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 RUBCN SRF USP3 USP50 ZFYVE21	5 interacting genes: ACE2 AKT1 HSP90AA1 HSP90AB1 PYCARD
Entrez ID		29108	373509
HPRD ID		06020	15639
Ensembl ID		ENSG00000103490	ENSG00000170236
Uniprot IDs		Q9ULZ3	Q70EL3
PDB IDs		1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H 7E5B 7KEU
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Canonical Inflammasome Complex Pyroptotic Inflammatory Response Regulation Of Interleukin-18 Production Positive Regulation Of Inflammatory Response NLRP3 Inflammasome Complex Regulation Of Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of NLRP3 Inflammasome Complex Assembly Cysteine-type Endopeptidase Activator Activity Positive Regulation Of Interleukin-18 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Defense Response IPAF Inflammasome Complex Regulation Of Defense Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Inflammatory Response Positive Regulation Of Innate Immune Response Immune System Process Immune Response-activating Signaling Pathway NLRP1 Inflammasome Complex Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Osmosensory Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Interleukin-18-mediated Signaling Pathway Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response Negative Regulation Of Cytokine Production Positive Regulation Of Immune Response Cysteine-type Peptidase Activity Response To Other Organism	Nitric-oxide Synthase Regulator Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Response To Heat Dendritic Growth Cone TPR Domain Binding Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cellular Component Biogenesis Secretory Granule Lumen Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Positive Regulation Of Striated Muscle Contraction Adhesion Of Symbiont To Host Response To Temperature Stimulus Regulation Of Protein Modification Process Identical Protein Binding Positive Regulation Of Protein Localization To Cell Surface Regulation Of Protein Ubiquitination Protein Homodimerization Activity Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Activation Of Innate Immune Response Protein-containing Complex Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Regulation Of Defense Response Positive Regulation Of Transport Regulation Of Post-translational Protein Modification Nitric Oxide Metabolic Process Telomere Maintenance Via Telomere Lengthening Reactive Nitrogen Species Metabolic Process Maternal Process Involved In Female Pregnancy Positive Regulation Of Defense Response To Virus By Host Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Heart Contraction Regulation Of Protein Localization To Cell Surface Positive Regulation Of Innate Immune Response Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Defense Response To Virus By Host Tau Protein Binding Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Positive Regulation Of Muscle Contraction
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