PYCARD and NLRC4

Number of citations of the paper that reports this interaction (PMID 12646168)
31

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro)

		PYCARD	NLRC4
Gene Name		PYD and CARD domain containing	NLR family, CARD domain containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Intracellular Nucleus Cytoplasm Cytosol Spindle Microtubule IPAF Inflammasome Complex
	Molecular Function	Protease Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyrin Domain Binding Protein Homodimerization Activity Ion Channel Binding	Magnesium Ion Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Rac GTPase Activity Interleukin-1 Beta Production Negative Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Chemokine Secretion Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Activation Of Innate Immune Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Regulation Of Signal Transduction Detection Of Bacterium Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Innate Immune Response Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		The NLRP3 inflammasome Inflammasomes The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways The IPAF inflammasome Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF	5 interactors: BCL10 CASP1 NLRP4 NOD2 PYCARD
Entrez ID		29108	58484
HPRD ID		06020	06014
Ensembl ID		ENSG00000103490	ENSG00000091106
Uniprot IDs		Q9ULZ3	Q9NPP4
PDB IDs		1UCP 2KN6
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cytokine Secretion Regulation Of Endopeptidase Activity Regulation Of Protein Secretion Immune System Process Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Interleukin-1 Beta Production Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Cytokine Production Positive Regulation Of Hydrolase Activity Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion Positive Regulation Of Protein Transport Immune Response Positive Regulation Of Cytokine Production Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity	Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytokine Production Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Interleukin-1 Beta Production Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Secretion Immune Response Defense Response Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Activation Of Innate Immune Response Positive Regulation Of Peptidase Activity Interleukin-1 Beta Production Response To Other Organism Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Biotic Stimulus Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of T Cell Activation Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Positive Regulation Of Interleukin-10 Production Regulation Of Inflammatory Response Positive Regulation Of Interleukin-8 Production Regulation Of T Cell Activation Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion
Tagcloud ?		1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover	advance aim2 antagonizes asc card doi excessive icb immunology inflammasome lipopolysaccharide nlrp3 oligomeric oligomerization online polymerization proinflammatory publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally
Tagcloud (Difference) ?		1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammation initiate lean mhcii nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover	advance aim2 antagonizes asc card doi excessive icb immunology lipopolysaccharide oligomeric oligomerization online polymerization proinflammatory publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally
Tagcloud (Intersection) ?		inflammasome nlrp3