PYCARD and NLRP12

Number of citations of the paper that reports this interaction (PubMedID 12019269)
0

Data Source:
HPRD (in vivo)

		PYCARD	NLRP12
Description		PYD and CARD domain containing	NLR family pyrin domain containing 12
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule IkappaB Kinase Complex Membrane Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex NLRP6 Inflammasome Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Myosin I Binding Enzyme Binding Pyrin Domain Binding Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activator Activity	Nucleotide Binding Protein Binding ATP Binding Protein-macromolecule Adaptor Activity Cysteine-type Endopeptidase Activator Activity
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Response To Bacterium Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Macropinocytosis NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Pyroptotic Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Cytokine Production Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Dendritic Cell Migration Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses	SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Post bronchodilator FEV1 ( 26634245)	Fasting glucose ( 33381925) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Testicular germ cell tumor ( 28604728)
Interacting Genes		15 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 RUBCN SRF USP3 USP50 ZFYVE21	3 interacting genes: FAF1 IRAK1 PYCARD
Entrez ID		29108	91662
HPRD ID		06020	14803
Ensembl ID		ENSG00000103490	ENSG00000142405
Uniprot IDs		Q9ULZ3	P59046
PDB IDs		1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H 7E5B 7KEU	2L6A 4XHS 5H7N
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Canonical Inflammasome Complex Pyroptotic Inflammatory Response Regulation Of Interleukin-18 Production Positive Regulation Of Inflammatory Response NLRP3 Inflammasome Complex Regulation Of Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of NLRP3 Inflammasome Complex Assembly Cysteine-type Endopeptidase Activator Activity Positive Regulation Of Interleukin-18 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Defense Response IPAF Inflammasome Complex Regulation Of Defense Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Inflammatory Response Positive Regulation Of Innate Immune Response Immune System Process Immune Response-activating Signaling Pathway NLRP1 Inflammasome Complex Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Osmosensory Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Interleukin-18-mediated Signaling Pathway Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response Negative Regulation Of Cytokine Production Positive Regulation Of Immune Response Cysteine-type Peptidase Activity Response To Other Organism	Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Heat Shock Protein Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Interleukin-1 Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Myosin I Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Ooplasm Fas Signaling Pathway AIM2 Inflammasome Complex Myeloid Dendritic Cell Activation Involved In Immune Response Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Stress Toll Signaling Pathway Positive Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Positive Regulation Of Cell Communication Positive Regulation Of Innate Immune Response Positive Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Interleukin-6 Receptor Binding IkappaB Kinase Complex Macropinocytosis Immune Response-activating Signaling Pathway Interleukin-33-mediated Signaling Pathway Osmosensory Signaling Pathway
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