PYCARD and NLRP3

Number of citations of the paper that reports this interaction (PMID 11786556)
39

Data Source:
HPRD (in vitro)

		PYCARD	NLRP3
Gene Name		PYD and CARD domain containing	NLR family, pyrin domain containing 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Cytoplasm Cytosol NLRP3 Inflammasome Complex
	Molecular Function	Protease Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyrin Domain Binding Protein Homodimerization Activity Ion Channel Binding	Protein Binding ATP Binding Peptidoglycan Binding
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Rac GTPase Activity Interleukin-1 Beta Production Negative Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Chemokine Secretion Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Acute Inflammatory Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Interleukin-18 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Interleukin-1 Secretion Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Defense Response To Virus Cellular Response To Lipopolysaccharide
Pathways		The NLRP3 inflammasome Inflammasomes The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS			C-reactive protein ( 21300955) Fibrinogen ( 20031576) Word reading ( 23738518)
Protein-Protein Interactions		11 interactors: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF	3 interactors: CARD8 FAF1 PYCARD
Entrez ID		29108	114548
HPRD ID		06020	05915
Ensembl ID		ENSG00000103490	ENSG00000162711
Uniprot IDs		Q9ULZ3	B2RC97 Q96P20
PDB IDs		1UCP 2KN6	3QF2
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cytokine Secretion Regulation Of Endopeptidase Activity Regulation Of Protein Secretion Immune System Process Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Interleukin-1 Beta Production Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Cytokine Production Positive Regulation Of Hydrolase Activity Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion Positive Regulation Of Protein Transport Immune Response Positive Regulation Of Cytokine Production Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Negative Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Apoptotic Process Regulation Of Cell Death Protein Processing Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Secretion Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Transport
Tagcloud ?		1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover	allergy alleviation arthropathy aseptic boy cerebrospinal china corticosteroid fever fundus hearing joints leucocytosis meningitis multisystem nomid normalization november peking persistently phe568lle pubmed rash searching statue summarized t1702t urticaria ventriculomegaly
Tagcloud (Difference) ?		1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover	allergy alleviation arthropathy aseptic boy cerebrospinal china corticosteroid fever fundus hearing joints leucocytosis meningitis multisystem nomid normalization november peking persistently phe568lle pubmed rash searching statue summarized t1702t urticaria ventriculomegaly
Tagcloud (Intersection) ?		nlrp3