EPHB4

Description		EPH receptor B4
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GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Blond vs. brown/black hair color ( 30531825) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Platelet distribution width ( 32888494) Resting heart rate ( 27798624) Takayasu arteritis ( 33308445)
Novel Interacting Genes		4 novel interacting genes: CLDN3 DNAJB6 EMILIN1 MAP3K4
Interacting Genes		7 interacting genes: APP DTX3 EFNB2 FBXO7 GRIN1 SDC3 VCP
Entrez ID		2050
HPRD ID		02481
Ensembl ID		ENSG00000196411
Uniprot IDs		P54760 Q541P7 Q96L35
PDB IDs		2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Glutamate Receptor Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Synaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Response To Light Stimulus Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Biological Quality Amylin Binding Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Metabolic Process Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Response To Amyloid-beta Cell Adhesion Protein-containing Complex Lipoprotein Particle Extracellular Matrix Organization Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Extracellular Structure Organization Identical Protein Binding Negative Regulation Of Phosphate Transmembrane Transport Positive Regulation Of Wound Healing Establishment Of Endothelial Blood-brain Barrier Positive Regulation Of Aorta Morphogenesis Response To Glycine Propylene Metabolic Process Male Germ-line Sex Determination Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination EMILIN Complex
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