GRIN3A and GRIN2A

Number of citations of the paper that reports this interaction (PMID 12391275)
12

Data Source:
HPRD (in vivo)

		GRIN3A	GRIN2A
Gene Name		glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Membrane Integral Component Of Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Glycine Binding Neurotransmitter Binding Identical Protein Binding Protein Phosphatase 2A Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding
	Biological Process	Calcium Ion Transport Dendrite Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Rhythmic Process Prepulse Inhibition Calcium Ion Transmembrane Transport	Startle Response Response To Amphetamine Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Or Memory Memory Protein Localization Visual Learning Response To Wounding Sensory Perception Of Pain Neurogenesis Sleep Directional Locomotion Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Response To Drug Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Tramadol Methadone Ethopropazine Dextromethorphan Acamprosate Procaine Ethanol Amantadine Felbamate Memantine Halothane Chloroprocaine Orphenadrine Ketamine Tenocyclidine Rolicyclidine Phencyclidine	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
Diseases
GWAS		Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Hepatitis B ( 22004137) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		5 interactors: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B	27 interactors: ACTN1 AP1M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 INADL NEDD4 PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC
Entrez ID		116443	2903
HPRD ID		09443	00698
Ensembl ID		ENSG00000198785	ENSG00000183454
Uniprot IDs		Q8TCU5	B4DII7 F5GZ52 Q12879 Q547U9 Q59EW6
PDB IDs			3NFL
Enriched GO Terms of Interacting Partners?		Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Depolarization Neuromuscular Process Learning Regulation Of Synaptic Plasticity Startle Response Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Learning Or Memory Regulation Of Membrane Potential Cognition Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Of Pain Single-organism Behavior Memory Synaptic Transmission Behavior Response To Ethanol Calcium Ion Transmembrane Transport Suckling Behavior Nervous System Development Cell-cell Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Response To Amphetamine Calcium Ion Transport Social Behavior Neurological System Process Positive Regulation Of Membrane Potential Locomotion Regulation Of Signaling Axon Guidance Response To Amine Regulation Of Neuronal Synaptic Plasticity Visual Learning Visual Behavior Axonogenesis Neurogenesis Associative Learning Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Ephrin Receptor Signaling Pathway Response To External Stimulus Feeding Behavior	Synaptic Transmission Cell-cell Signaling Protein Localization To Synapse Chemotaxis Neuron Projection Development Receptor Localization To Synapse Neuron Development Locomotion Axon Guidance Regulation Of Ion Transport Neuron Differentiation Cell Projection Organization Response To External Stimulus Protein Autophosphorylation Receptor Clustering Generation Of Neurons Axonogenesis Nucleotide Phosphorylation Neurogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Membrane Organization Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Regulation Of Synaptic Plasticity Nervous System Development Cell Morphogenesis Involved In Differentiation Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Cell Projection Morphogenesis Cell Development Peptidyl-serine Phosphorylation Cell Part Morphogenesis Phosphorylation Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell Communication Cell Activation Phosphate-containing Compound Metabolic Process Glutamate Receptor Signaling Pathway Cell Differentiation Response To Stimulus Immune Response Regulation Of Cell Projection Organization Regulation Of Synaptic Transmission Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?