NKX3-1 and PTMS

Number of citations of the paper that reports this interaction (PubMedID 18816836)
45

Data Source:
BioGRID (two hybrid)

		NKX3-1	PTMS
Description		NK3 homeobox 1	parathymosin
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage	Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Prostate Gland Development Regulation Of Protein Localization Response To Testosterone Response To Lipid Dorsal Aorta Development Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immune System Process DNA Replication Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Prostate cancer
GWAS		Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 26443449 32986714 34012061) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		38 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MRE11 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC67A1 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417	8 interacting genes: APP GET4 NKX3-1 NR3C1 RXRB SCHIP1 SDCBP2 SMAD2
Entrez ID		4824	5763
HPRD ID		03620	01344
Ensembl ID		ENSG00000167034	ENSG00000159335
Uniprot IDs		Q99801	A0A158RFU3 F5GXR3 P20962
PDB IDs		2L9R
Enriched GO Terms of Interacting Partners?		Nucleus DNA Binding PML Body Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Trachea Cartilage Development Sequence-specific Double-stranded DNA Binding Embryonic Eye Morphogenesis Glandular Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Double-stranded DNA Binding Regulation Of Programmed Cell Death DNA Damage Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Eye Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sensory Organ Morphogenesis Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Morphogenesis Zinc Ion Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Trophectodermal Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Face Development Regulation Of Macromolecule Biosynthetic Process Prostate Gland Epithelium Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To Stress Replication Fork Positive Regulation Of Macromolecule Metabolic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Thyroid Gland Development	Positive Regulation Of Transcription By RNA Polymerase II Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor Activity DNA-binding Transcription Factor Activity Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Identical Protein Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Reproductive Behavior Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway DNA Binding Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Nuclear Glucocorticoid Receptor Activity Response To Lipid Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Neuron Apoptotic Process Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Nucleoplasm Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Acetylcholine Receptor Activator Activity Positive Regulation Of Cell Communication Regulation Of MiRNA Metabolic Process Positive Regulation Of Signaling Lipoprotein Particle Positive Regulation Of Protein Import RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Tissue Morphogenesis Homomeric SMAD Protein Complex Dorsal Aorta Development
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