NKX3-1 and SP5

Number of citations of the paper that reports this interaction (PMID 16201967)
10

Data Source:
BioGRID (two hybrid)

		NKX3-1	SP5
Gene Name		NK3 homeobox 1	Sp5 transcription factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Androgen Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Protein Kinase Activator Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association Transcription Regulatory Region DNA Binding MADS Box Domain Binding	Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Salivary Gland Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Hormone Mediated Signaling Pathway Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Post-anal Tail Morphogenesis Bone Morphogenesis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: AEN CCT7 CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 ND4 PEBP1 PTMS RABL6 RARG RPL37A RPSA SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 STRA13 TEX264 TOPORS TPT1 WDR77	1 interactors: NKX3-1
Entrez ID		4824	389058
HPRD ID		03620	18088
Ensembl ID		ENSG00000167034	ENSG00000204335
Uniprot IDs		Q99801	Q6BEB4
PDB IDs		2L9R
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Embryonic Eye Morphogenesis Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Embryonic Camera-type Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Eye Morphogenesis Biosynthetic Process Megakaryocyte Differentiation Trophectodermal Cell Differentiation Camera-type Eye Development Eye Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Erythrocyte Differentiation Erythrocyte Homeostasis Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Camera-type Eye Morphogenesis Organ Morphogenesis Myeloid Cell Homeostasis Organ Development Embryonic Organ Development Glandular Epithelial Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Embryonic Process Involved In Female Pregnancy Sensory Organ Development Prostate Gland Development Regulation Of RNA Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Tissue Development System Development Homeostasis Of Number Of Cells	Positive Regulation Of Androgen Secretion Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Receptor Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Dorsal Aorta Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Mitotic Cell Cycle Arrest Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Branching Involved In Prostate Gland Morphogenesis Pharyngeal System Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Aorta Development Response To Testosterone Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Androgen Receptor Signaling Pathway Prostate Gland Morphogenesis Salivary Gland Morphogenesis Salivary Gland Development Negative Regulation Of Protein Binding Cellular Response To Drug Cellular Response To Interleukin-1 Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lipid Transport Exocrine System Development Artery Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Response To DNA Damage Stimulus Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Somitogenesis Response To Interleukin-1 Epithelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Lipid Transport Activation Of Cysteine-type Endopeptidase Activity Somite Development Cellular Response To Hypoxia Negative Regulation Of Binding Cellular Response To Decreased Oxygen Levels Cellular Response To Tumor Necrosis Factor Positive Regulation Of Hormone Secretion Steroid Hormone Mediated Signaling Pathway Metanephros Development Zymogen Activation Cellular Response To Oxygen Levels Segmentation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
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