CXCL1

Gene Name		chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Receptor Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization Response To Lipopolysaccharide Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-protein Interactions		5 interactors: ACKR1 CXCR1 CXCR2 HIPK2 MMP9
Entrez ID		2919
HPRD ID		01119
Ensembl ID		ENSG00000163739
Uniprot IDs		P09341
PDB IDs		1MGS 1MSG 1MSH 1ROD
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Leukocyte Migration Dendritic Cell Migration Receptor Internalization Cell Surface Receptor Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Binding Receptor Metabolic Process Cellular Response To Cytokine Stimulus Chemotaxis Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Neutrophil Apoptotic Process Response To Cytokine Positive Regulation Of Binding Positive Regulation Of Angiogenesis Immune System Process Regulation Of Protein Binding Cell Migration Cell Chemotaxis Cell Motility Signal Transduction Response To Organic Substance Signaling Positive Regulation Of Receptor Binding Voluntary Musculoskeletal Movement Regulation Of Angiogenesis Cell Communication Positive Regulation Of Keratinocyte Migration PML Body Organization Myeloid Cell Differentiation G-protein Coupled Receptor Signaling Pathway Regulation Of Binding Acute Inflammatory Response To Antigenic Stimulus Locomotion Defense Response Iris Morphogenesis Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Lens Induction In Camera-type Eye Metanephric Tubule Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Locomotion
Tagcloud ?		backgroundmonocyte ccl3 ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe