CXCL1 and CXCR2

Number of citations of the paper that reports this interaction (PMID 8702798)
57

Data Source:
HPRD (in vivo)

		CXCL1	CXCR2
Gene Name		chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	chemokine (C-X-C motif) receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule
	Molecular Function	Receptor Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization Response To Lipopolysaccharide Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Cell Chemotaxis Chemokine-mediated Signaling Pathway	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		5 interactors: ACKR1 CXCR1 CXCR2 HIPK2 MMP9	21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13
Entrez ID		2919	3579
HPRD ID		01119	00907
Ensembl ID		ENSG00000163739	ENSG00000180871
Uniprot IDs		P09341	P25025 Q53PC4
PDB IDs		1MGS 1MSG 1MSH 1ROD
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Leukocyte Migration Dendritic Cell Migration Receptor Internalization Cell Surface Receptor Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Binding Receptor Metabolic Process Cellular Response To Cytokine Stimulus Chemotaxis Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Neutrophil Apoptotic Process Response To Cytokine Positive Regulation Of Binding Positive Regulation Of Angiogenesis Immune System Process Regulation Of Protein Binding Cell Migration Cell Chemotaxis Cell Motility Signal Transduction Response To Organic Substance Signaling Positive Regulation Of Receptor Binding Voluntary Musculoskeletal Movement Regulation Of Angiogenesis Cell Communication Positive Regulation Of Keratinocyte Migration PML Body Organization Myeloid Cell Differentiation G-protein Coupled Receptor Signaling Pathway Regulation Of Binding Acute Inflammatory Response To Antigenic Stimulus Locomotion Defense Response Iris Morphogenesis Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Lens Induction In Camera-type Eye Metanephric Tubule Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Locomotion	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus
Tagcloud ?		backgroundmonocyte ccl3 ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?		backgroundmonocyte ccl3 ccl4 ccl7 cd45 conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	ab attenuating chemokine chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?		chemokines