CXCL1 and CXCL6

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CXCL1	CXCL6
Description		C-X-C motif chemokine ligand 1	C-X-C motif chemokine ligand 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Killing Of Cells Of Another Organism Intracellular Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Leukocyte Homeostasis Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Chemokine Production Neutrophil Activation Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cellular Response To Lipopolysaccharide Antibacterial Innate Immune Response
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Anxiety disorder ( 25390645) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3	14 interacting genes: CCL11 CCL5 CCL7 CCL8 CXCL1 CXCL10 CXCL12 CXCL2 CXCL3 CXCR1 CXCR2 MMP9 PF4 PPBP
Entrez ID		2919	6372
HPRD ID		01119	00735
Ensembl ID		ENSG00000163739	ENSG00000124875
Uniprot IDs		P09341	P80162
PDB IDs		1MGS 1MSG 1MSH 1ROD 8K4O 8XWA 8XWV	8XWM 8XXX
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Positive Regulation Of Cell Population Proliferation Chemotaxis Leukocyte Chemotaxis Neutrophil Chemotaxis Locomotion Neutrophil Migration Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Leukocyte Migration Interleukin-8 Receptor Activity C-C Chemokine Binding Cell Migration Interleukin-8 Binding Cell Motility Regulation Of Cell Population Proliferation Chemokine Activity Cytokine-mediated Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway C-X-C Chemokine Receptor Activity Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Inflammatory Response CXCR Chemokine Receptor Binding Dendritic Cell Chemotaxis Response To Stress Branching Involved In Mammary Gland Duct Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Intracellular Signal Transduction Immune Response Chemokine Receptor Activity C-C Chemokine Receptor Activity Dendritic Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Antimicrobial Humoral Response Defense Response Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Cellular Response To Lipid Negative Regulation Of Programmed Cell Death Cellular Response To Molecule Of Bacterial Origin Fibroblast Proliferation Cytokine Activity Regulation Of Cell Migration Regulation Of Cell Motility	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Granulocyte Chemotaxis Leukocyte Chemotaxis Granulocyte Migration Antimicrobial Humoral Response Cytokine Activity Myeloid Leukocyte Migration Leukocyte Migration Cell Migration Humoral Immune Response Cell Motility Killing Of Cells Of Another Organism Chemokine-mediated Signaling Pathway Cell Killing Inflammatory Response Immune Response Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Neutrophil Chemotaxis Response To External Biotic Stimulus Immune System Process Defense Response Cytokine-mediated Signaling Pathway Neutrophil Migration Extracellular Space Response To Other Organism G Protein-coupled Receptor Signaling Pathway CXCR Chemokine Receptor Binding Extracellular Region Eosinophil Chemotaxis Eosinophil Migration Signal Transduction CCR Chemokine Receptor Binding Positive Regulation Of Lymphocyte Migration Response To Stress Positive Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Dendritic Cell Chemotaxis Calcium Ion Homeostasis Interleukin-8-mediated Signaling Pathway
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