WSB1 and AXIN1

Number of citations of the paper that reports this interaction (PubMedID 35530152)
45

Data Source:
BioGRID (pull down)

		WSB1	AXIN1
Description		WD repeat and SOCS box containing 1	axin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Cell Periphery Wnt Signalosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	P53 Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding Protein Serine/threonine Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Intracellular Signal Transduction Protein K27-linked Ubiquitination Protein Aggregate Center Assembly	Protein Polyubiquitination In Utero Embryonic Development Nucleocytoplasmic Transport Apoptotic Process Sensory Perception Of Sound Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Wnt Signaling Pathway Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Post-anal Tail Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of JNK Cascade Axial Mesoderm Development Axial Mesoderm Formation Cell Development Negative Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Head Development Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs			1,4-Dithiothreitol
Diseases			Caudal duplication anomaly Hepatocellular carcinoma
GWAS		Birth weight ( 31043758) Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)
Interacting Genes		8 interacting genes: AXIN1 CSF3R DIO2 HIPK2 LRRK2 UBE2D2 UBE2D3 VHL	91 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 FXR1 FXR2 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KAT5 KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RCHY1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSC1 TSGA10 UCHL5 USP10 USP7 UTP14A WSB1 ZBTB26 ZFYVE19
Entrez ID		26118	8312
HPRD ID		15680	04819
Ensembl ID		ENSG00000109046	ENSG00000103126
Uniprot IDs		Q8NC76 Q9Y6I7	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs			1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK 7SXF 7SXG 7SXH 7SXJ 7Y1P 8RU3 8RU4 8VMG
Enriched GO Terms of Interacting Partners?		Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Wnt Signalosome Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Protein Polyubiquitination Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Cell Communication Negative Regulation Of Signaling SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Post-translational Protein Modification Granulocyte Colony-stimulating Factor Binding Protein Autoubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of BMP Signaling Pathway Beta-catenin Destruction Complex Assembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Regulation Of Transcription Elongation By RNA Polymerase II Canonical Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Axial Mesoderm Formation Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion	Wnt Signaling Pathway Cytoplasm Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Wnt Signalosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-catenin Destruction Complex Signal Transduction Beta-catenin Binding PML Body Positive Regulation Of Biosynthetic Process
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