WSB1 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 15965468)
35

Data Source:
BioGRID (enzymatic study)

		WSB1	DIO2
Description		WD repeat and SOCS box containing 1	iodothyronine deiodinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Intracellular Signal Transduction Protein K27-linked Ubiquitination Protein Aggregate Center Assembly	Selenocysteine Incorporation Thyroid Hormone Generation Response To Lipopolysaccharide Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Regulation of thyroid hormone activity Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)	Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		8 interacting genes: AXIN1 CSF3R DIO2 HIPK2 LRRK2 UBE2D2 UBE2D3 VHL	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		26118	1734
HPRD ID		15680	09027
Ensembl ID		ENSG00000109046	ENSG00000211448
Uniprot IDs		Q8NC76 Q9Y6I7	A8K845 Q92813
PDB IDs
Enriched GO Terms of Interacting Partners?		Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Wnt Signalosome Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Protein Polyubiquitination Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Cell Communication Negative Regulation Of Signaling SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Post-translational Protein Modification Granulocyte Colony-stimulating Factor Binding Protein Autoubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of BMP Signaling Pathway Beta-catenin Destruction Complex Assembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Regulation Of Transcription Elongation By RNA Polymerase II Canonical Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Axial Mesoderm Formation Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion	Post-translational Protein Modification Protein Modification Process Protein Polyubiquitination Proteolysis Protein Ubiquitination Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity G Protein-coupled Receptor Binding ER Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Cysteine-type Deubiquitinase Activity ERAD Pathway Macromolecule Metabolic Process Protein Deubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Removal Protein Aggregate Center Assembly Protein Catabolic Process Cysteine-type Peptidase Activity VCB Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Catabolic Process Hrd1p Ubiquitin Ligase Complex Response To Endoplasmic Reticulum Stress Negative Regulation Of Cholesterol Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Cholesterol Metabolic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Glycoprotein Metabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Ubiquitin Protein Ligase Binding Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding Regulation Of Autophagy Centrosome Duplication Protein Deglycosylation
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