WSB1 and DIO2

Number of citations of the paper that reports this interaction (PMID 15965468)
47

Data Source:
BioGRID (enzymatic study)

		WSB1	DIO2
Gene Name		WD repeat and SOCS box containing 1	deiodinase, iodothyronine, type II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding
	Biological Process	Biological_process Protein Ubiquitination Intracellular Signal Transduction	Selenocysteine Incorporation Thyroid Hormone Generation Cellular Nitrogen Compound Metabolic Process Thyroid Hormone Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS		Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)
Protein-Protein Interactions		5 interactors: CSF3R DIO2 GSK3B HIPK2 UBE2D3	6 interactors: MARCH6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		26118	1734
HPRD ID		15680	09027
Ensembl ID		ENSG00000109046	ENSG00000211448
Uniprot IDs		B4DGB8 Q9Y6I7	A8K845 Q92813 Q9HCP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Response To Oxygen Levels Peptidyl-serine Phosphorylation Positive Regulation Of Binding Immune System Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Thyroid Hormone Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Response To Organic Substance Response To Transforming Growth Factor Beta Apoptotic Process Organ Morphogenesis Programmed Cell Death Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Voluntary Musculoskeletal Movement Cell Death Death Response To Abiotic Stimulus PML Body Organization Cellular Response To Interleukin-3 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Selenocysteine Incorporation Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Surface Receptor Signaling Pathway Response To Hypoxia Hormone Catabolic Process Protein Localization To Microtubule Defense Response Negative Regulation Of Biosynthetic Process Iris Morphogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Response To Stress Apoptotic Signaling Pathway Lens Induction In Camera-type Eye ER Overload Response	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein K63-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Catabolic Process Protein Polyubiquitination Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Protein K63-linked Ubiquitination Centrosome Duplication ER-associated Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of Proteolysis Negative Regulation Of Protein Binding Centrosome Cycle Positive Regulation Of Protein Binding
Tagcloud ?		293t carrier chimera chimeric d2 deiodinase deiodinases deiodination direction e3 extensively globular govern hek insertion instability introducing k237 k244 ligase lysines march6 readily teb4 thyroxine transiently ubiquitinate ubiquitination unless	cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Difference) ?		293t carrier chimera chimeric d2 deiodinases deiodination direction e3 extensively globular govern hek insertion instability introducing k237 k244 ligase lysines march6 readily teb4 transiently ubiquitinate ubiquitination unless	cga hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin trh trhr triiodothyronine tsh tshb
Tagcloud (Intersection) ?		deiodinase thyroxine