GRIK1 and GRIP1

Number of citations of the paper that reports this interaction (PMID 12597860)
60

Data Source:
BioGRID (pull down)

		GRIK1	GRIP1
Gene Name		glutamate receptor, ionotropic, kainate 1	glutamate receptor interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density	Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Dendrite Neuron Projection Membrane Raft Postsynaptic Membrane Recycling Endosome
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Receptor Signaling Complex Scaffold Activity Glucocorticoid Receptor Binding Androgen Receptor Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Nervous System Development Central Nervous System Development Positive Regulation Of Gamma-aminobutyric Acid Secretion Adult Behavior Positive Regulation Of Synaptic Transmission, GABAergic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Behavioral Response To Pain Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Synaptic Transmission Protein Localization Dendrite Development Androgen Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Topiramate
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Response to statin therapy ( 20339536)
Protein-Protein Interactions		6 interactors: DLG4 FLNA GRIP1 HOMER1 PICK1 SDCBP	34 interactors: AR CARM1 CSPG4 EFNA5 EFNB1 EFNB2 EP300 ESR1 FLII GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIPAP1 GRM3 HIST1H3A IRF3 NCOA6 NR2F1 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA RXRB THRA UBE2I VDR
Entrez ID		2897	23426
HPRD ID		00693	19086
Ensembl ID		ENSG00000171189	ENSG00000155974
Uniprot IDs		E7EPY9 E7EPZ0 E9PD61 P39086	Q9Y3R0
PDB IDs		2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO	2JIL
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Receptor Clustering Cell Development Protein Localization Cell-cell Signaling Protein Localization To Membrane Cell Projection Organization Protein Localization To Synapse Cell Differentiation Dendritic Spine Organization Positive Regulation Of Transport Regulation Of Receptor Internalization Membrane Organization System Development Neuron Development Multicellular Organismal Development Neuron Differentiation Regulation Of Vesicle-mediated Transport Anatomical Structure Development Signal Transduction Cellular Protein Localization Developmental Process Signaling Establishment Of Protein Localization Regulation Of Signaling Cell Communication Intracellular Transport Generation Of Neurons Actin Cytoskeleton Organization Neurogenesis Actin Filament-based Process Dendrite Development Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Establishment Of Localization In Cell Regulation Of Synaptic Plasticity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Endocytosis Positive Regulation Of Extracellular Vesicular Exosome Assembly Nervous System Development Cellular Localization Regulation Of Extracellular Vesicular Exosome Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Morphogenesis	Intracellular Receptor Signaling Pathway Signal Transduction Glutamate Receptor Signaling Pathway Signaling Cell Communication Steroid Hormone Mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Synaptic Transmission, Glutamatergic Cellular Response To Stimulus DNA-templated Transcription, Initiation Cellular Response To Steroid Hormone Stimulus Neuron-neuron Synaptic Transmission Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Response To Organic Cyclic Compound Cell-cell Signaling Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Response To Lipid Multicellular Organismal Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Synaptic Transmission Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Organic Substance Cellular Response To Organic Substance Synaptic Transmission Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Developmental Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process
Tagcloud ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron neuroplasticity online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones	acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable src
Tagcloud (Difference) ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron neuroplasticity online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones	acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable src
Tagcloud (Intersection) ?