GRIK1 and HOMER1

Number of citations of the paper that reports this interaction (PMID 9069287)
135

Data Source:
HPRD (in vivo, in vitro)

		GRIK1	HOMER1
Gene Name		glutamate receptor, ionotropic, kainate 1	homer homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density	Z Disc Cell Junction Axon Neuronal Cell Body Costamere Dendritic Shaft Apical Part Of Cell Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity	Type 5 Metabotropic Glutamate Receptor Binding Protein Complex Scaffold G-protein Coupled Glutamate Receptor Binding Signaling Adaptor Activity Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Nervous System Development Central Nervous System Development Positive Regulation Of Gamma-aminobutyric Acid Secretion Adult Behavior Positive Regulation Of Synaptic Transmission, GABAergic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Behavioral Response To Pain Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Skeletal Muscle Contraction Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Circadian Rhythm Positive Regulation Of Signal Transduction Response To Nicotine Protein Localization To Synapse Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Topiramate
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Response to statin therapy ( 20339536)	Height ( 18193045) Major depressive disorder ( 20673876)
Protein-Protein Interactions		6 interactors: DLG4 FLNA GRIP1 HOMER1 PICK1 SDCBP	19 interactors: ABI3 AGAP2 C19orf57 C1orf116 DNM3 EFNB2 FAT1 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 RYR1 RYR2 SHANK1 STX12 TANC1 TRPC1
Entrez ID		2897	9456
HPRD ID		00693	09211
Ensembl ID		ENSG00000171189
Uniprot IDs		E7EPY9 E7EPZ0 E9PD61 P39086	Q5U5K4 Q86YM7
PDB IDs		2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Receptor Clustering Cell Development Protein Localization Cell-cell Signaling Protein Localization To Membrane Cell Projection Organization Protein Localization To Synapse Cell Differentiation Dendritic Spine Organization Positive Regulation Of Transport Regulation Of Receptor Internalization Membrane Organization System Development Neuron Development Multicellular Organismal Development Neuron Differentiation Regulation Of Vesicle-mediated Transport Anatomical Structure Development Signal Transduction Cellular Protein Localization Developmental Process Signaling Establishment Of Protein Localization Regulation Of Signaling Cell Communication Intracellular Transport Generation Of Neurons Actin Cytoskeleton Organization Neurogenesis Actin Filament-based Process Dendrite Development Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Establishment Of Localization In Cell Regulation Of Synaptic Plasticity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Endocytosis Positive Regulation Of Extracellular Vesicular Exosome Assembly Nervous System Development Cellular Localization Regulation Of Extracellular Vesicular Exosome Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Morphogenesis	Glutamate Receptor Signaling Pathway Cell-cell Signaling Cytosolic Calcium Ion Homeostasis G-protein Coupled Glutamate Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Homeostasis Regulation Of Sequestering Of Calcium Ion Behavior Regulation Of Ion Transport Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Transport Regulation Of Ion Homeostasis Cellular Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Synaptic Transmission, Glutamatergic Cellular Cation Homeostasis Calcium Ion Transmembrane Transport Cellular Ion Homeostasis Single-organism Behavior Metal Ion Homeostasis Developmental Process Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Chemical Homeostasis Learning Or Memory Ion Homeostasis Cognition Synaptic Transmission Regulation Of Synaptic Transmission Calcium Ion Transport Dendritic Spine Organization Cellular Homeostasis Learning Cell Projection Organization Response To Caffeine Multicellular Organismal Development Anatomical Structure Morphogenesis Ion Transmembrane Transport Anatomical Structure Development Chemical Homeostasis Regulation Of Calcium Ion Transport Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Alkaloid Positive Regulation Of Ion Transport Synaptic Transmission, Glutamatergic Long-term Memory Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Determination Of Affect
Tagcloud ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron neuroplasticity online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?		neuroplasticity