GRIP1 and CARM1

Number of citations of the paper that reports this interaction (PubMedID 17882261)
46

Data Source:
BioGRID (pull down)

		GRIP1	CARM1
Description		glutamate receptor interacting protein 1	coactivator associated arginine methyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Replication Fork
	Molecular Function	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H3R17 Methyltransferase Activity Histone Methyltransferase Activity Histone H3R2 Methyltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Positive Regulation Of Cell Population Proliferation Methylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Response To CAMP Replication Fork Reversal Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Dendrite Development
Pathways		Trafficking of GluR2-containing AMPA receptors	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)	C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624)
Interacting Genes		46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH	34 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I
Entrez ID		23426	10498
HPRD ID		19086	09158
Ensembl ID		ENSG00000155974	ENSG00000142453
Uniprot IDs		A0A8V8TLS6 Q9Y3R0	Q86X55
PDB IDs		2JIL	2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C 7FAI 7FAJ 7U9I 8G2H 8G2I 8SIG 8SIH
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Transcription Coactivator Activity Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Enzyme Binding Muscle Cell Differentiation Positive Regulation Of Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Regulation Of Cell Development
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