GRIK1 and DLG4

Number of citations of the paper that reports this interaction (PMID 12597860)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		GRIK1	DLG4
Gene Name		glutamate receptor, ionotropic, kainate 1	discs, large homolog 4 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Nervous System Development Central Nervous System Development Positive Regulation Of Gamma-aminobutyric Acid Secretion Adult Behavior Positive Regulation Of Synaptic Transmission, GABAergic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Behavioral Response To Pain Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Topiramate
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Response to statin therapy ( 20339536)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		6 interactors: DLG4 FLNA GRIP1 HOMER1 PICK1 SDCBP	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		2897	1742
HPRD ID		00693	04199
Ensembl ID		ENSG00000171189	ENSG00000132535
Uniprot IDs		E7EPY9 E7EPZ0 E9PD61 P39086	B7Z647 B9EGL1 P78352
PDB IDs		2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO	1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Receptor Clustering Cell Development Protein Localization Cell-cell Signaling Protein Localization To Membrane Cell Projection Organization Protein Localization To Synapse Cell Differentiation Dendritic Spine Organization Positive Regulation Of Transport Regulation Of Receptor Internalization Membrane Organization System Development Neuron Development Multicellular Organismal Development Neuron Differentiation Regulation Of Vesicle-mediated Transport Anatomical Structure Development Signal Transduction Cellular Protein Localization Developmental Process Signaling Establishment Of Protein Localization Regulation Of Signaling Cell Communication Intracellular Transport Generation Of Neurons Actin Cytoskeleton Organization Neurogenesis Actin Filament-based Process Dendrite Development Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Establishment Of Localization In Cell Regulation Of Synaptic Plasticity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Endocytosis Positive Regulation Of Extracellular Vesicular Exosome Assembly Nervous System Development Cellular Localization Regulation Of Extracellular Vesicular Exosome Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Morphogenesis	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron neuroplasticity online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron neuroplasticity online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?