GRIK1

Gene Name		glutamate receptor, ionotropic, kainate 1
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Nervous System Development Central Nervous System Development Positive Regulation Of Gamma-aminobutyric Acid Secretion Adult Behavior Positive Regulation Of Synaptic Transmission, GABAergic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Behavioral Response To Pain Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Topiramate
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Response to statin therapy ( 20339536)
Protein-protein Interactions		6 interactors: DLG4 FLNA GRIP1 HOMER1 PICK1 SDCBP
Entrez ID		2897
HPRD ID		00693
Ensembl ID		ENSG00000171189
Uniprot IDs		E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs		2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Receptor Clustering Cell Development Protein Localization Cell-cell Signaling Protein Localization To Membrane Cell Projection Organization Protein Localization To Synapse Cell Differentiation Dendritic Spine Organization Positive Regulation Of Transport Regulation Of Receptor Internalization Membrane Organization System Development Neuron Development Multicellular Organismal Development Neuron Differentiation Regulation Of Vesicle-mediated Transport Anatomical Structure Development Signal Transduction Cellular Protein Localization Developmental Process Signaling Establishment Of Protein Localization Regulation Of Signaling Cell Communication Intracellular Transport Generation Of Neurons Actin Cytoskeleton Organization Neurogenesis Actin Filament-based Process Dendrite Development Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Establishment Of Localization In Cell Regulation Of Synaptic Plasticity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Endocytosis Positive Regulation Of Extracellular Vesicular Exosome Assembly Nervous System Development Cellular Localization Regulation Of Extracellular Vesicular Exosome Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Morphogenesis
Tagcloud ?		21q 2n app considerable differed epigenetic glur glutamate hypermethylation integrating kb learning located neural neuron neuroplasticity online precise precursor regard replication replicationdomain thp timing timings transition transitioned xy zones