GRIP1 and FLII

Number of citations of the paper that reports this interaction (PubMedID 14966289)
72

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		GRIP1	FLII
Description		glutamate receptor interacting protein 1	FLII actin remodeling protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane	Podosome Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Brush Border Focal Adhesion Actin Cytoskeleton Centriolar Satellite Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization	Actin Polymerization Or Depolymerization Myofibril Assembly Sarcomere Organization Actin Filament Severing Barbed-end Actin Filament Capping
Pathways		Trafficking of GluR2-containing AMPA receptors
Drugs
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH	15 interacting genes: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LCOR LRRFIP1 LRRFIP2 MYD88 NCOA2 OPTN PRMT1 RNF34 TRAIP
Entrez ID		23426	2314
HPRD ID		19086	02647
Ensembl ID		ENSG00000155974	ENSG00000177731
Uniprot IDs		A0A8V8TLS6 Q9Y3R0	Q13045
PDB IDs		2JIL
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding	Regulation Of DNA-templated Transcription Nucleoplasm Nitric-oxide Synthase Regulator Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Remodeling Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination Nucleus Intracellular Receptor Signaling Pathway Protein Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Brahma Complex Regulation Of Macromolecule Metabolic Process NpBAF Complex Regulation Of Double-strand Break Repair Via Homologous Recombination GBAF Complex Chromatin Organization RSC-type Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Double-strand Break Repair Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Beta-catenin Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA Recombination Positive Regulation Of DNA Repair Signal Transduction NuA4 Histone Acetyltransferase Complex Regulation Of Nucleotide-excision Repair Regulation Of Double-strand Break Repair SWI/SNF Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Methyltransferase Activity Protein-containing Complex Cellular Response To Estradiol Stimulus Negative Regulation Of Intracellular Signal Transduction Regulation Of G0 To G1 Transition Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Signal Transduction Nucleosomal DNA Binding
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