GRIK1 and GRIK3

Number of citations of the paper that reports this interaction (PubMedID 29058671)
59

Data Source:
BioGRID (pull down)

		GRIK1	GRIK3
Description		glutamate ionotropic receptor kainate type subunit 1	glutamate ionotropic receptor kainate type subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Plasma Membrane Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential	Monoatomic Ion Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential
Pathways		Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Activation of Ca-permeable Kainate Receptor Presynaptic function of Kainate receptors
Drugs		Glutamic acid Butabarbital Topiramate Tezampanel	Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Lung cancer ( 34062886) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Forced expiratory volume in 1 second (environmental tobacco smoke interaction) ( 28738859) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Metabolite levels ( 23823483) Neuroticism ( 27067015) Post bronchodilator FEV1/FVC ratio ( 26634245) Schizophrenia ( 23894747)
Interacting Genes		31 interacting genes: COPS5 CYSLTR2 DLG4 DLST DNAJB9 FLNA GORASP2 GRIK2 GRIK3 GRIK4 GRIK5 GRIP1 HOMER1 HSP90B1 KALRN KCNQ2 LDB2 PICK1 PTPRD RANBP9 RNF123 SDCBP SEPTIN7 SIPA1L3 SNAPIN SRI ST13 TAAR1 UBE2O ZFC3H1 ZNF592	4 interacting genes: FLNA GRIK1 GRIK4 GRIK5
Entrez ID		2897	2899
HPRD ID		00693	00691
Ensembl ID		ENSG00000171189	ENSG00000163873
Uniprot IDs		B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086	Q13003
PDB IDs		2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?		Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Regulation Of Cell Communication Regulation Of Signaling Synapse Cell-cell Signaling Signaling Cell Communication Modulation Of Chemical Synaptic Transmission Presynaptic Membrane Regulation Of Presynaptic Membrane Potential Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Hippocampal Mossy Fiber To CA3 Synapse Receptor Clustering Postsynaptic Membrane Localization Within Membrane Postsynaptic Density Monoatomic Ion Channel Activity Regulation Of Membrane Potential Dendrite Cytoplasm Protein Localization To Membrane Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Synaptic Transmission Glutamatergic Synapse Protein Sequestering Activity Plasma Membrane Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Synaptic Vesicle Negative Regulation Of Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Regulation Of Signal Transduction Perikaryon Glutamate Receptor Activity Protein-containing Complex Localization Cellular Localization Regulation Of Neuron Projection Arborization Regulation Of Synaptic Transmission, Glutamatergic	Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Membrane Potential Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Glutamate-gated Receptor Activity Presynaptic Membrane Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Monoatomic Ion Transport Postsynaptic Membrane Signaling Receptor Activity Regulation Of Presynaptic Membrane Potential Transmembrane Transport Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Hippocampal Mossy Fiber To CA3 Synapse Modulation Of Chemical Synaptic Transmission Cell-cell Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Synapse Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Glycoprotein Ib-IX-V Complex Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein Localization To Bicellular Tight Junction Cell Projection Regulation Of Cell Communication Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Signaling Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Blood Coagulation, Intrinsic Pathway Regulation Of Membrane Repolarization During Action Potential Glutamate-gated Calcium Ion Channel Activity Negative Regulation Of Transcription By RNA Polymerase I
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