GRIP1 and PRKD2

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		GRIP1	PRKD2
Gene Name		glutamate receptor interacting protein 1	protein kinase D2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Dendrite Neuron Projection Membrane Raft Postsynaptic Membrane Recycling Endosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Receptor Signaling Complex Scaffold Activity Glucocorticoid Receptor Binding Androgen Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Synaptic Transmission Protein Localization Dendrite Development Androgen Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461)
Protein-Protein Interactions		34 interactors: AR CARM1 CSPG4 EFNA5 EFNB1 EFNB2 EP300 ESR1 FLII GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIPAP1 GRM3 HIST1H3A IRF3 NCOA6 NR2F1 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA RXRB THRA UBE2I VDR	17 interactors: CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2
Entrez ID		23426	25865
HPRD ID		19086	09523
Ensembl ID		ENSG00000155974	ENSG00000105287
Uniprot IDs		Q9Y3R0	M0QZW1 M0R2R2 Q8NCK8 Q9BZL6
PDB IDs		2JIL	2COA 3BGM
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Signal Transduction Glutamate Receptor Signaling Pathway Signaling Cell Communication Steroid Hormone Mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Synaptic Transmission, Glutamatergic Cellular Response To Stimulus DNA-templated Transcription, Initiation Cellular Response To Steroid Hormone Stimulus Neuron-neuron Synaptic Transmission Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Response To Organic Cyclic Compound Cell-cell Signaling Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Response To Lipid Multicellular Organismal Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Synaptic Transmission Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Organic Substance Cellular Response To Organic Substance Synaptic Transmission Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Developmental Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process	Positive Regulation Of Gene Expression Regulation Of Osteoblast Differentiation Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Chamber Development Developmental Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Steroid Hormone Stimulus Multicellular Organismal Development Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Intracellular Receptor Signaling Pathway Heart Development Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Glandular Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Transcription, DNA-templated Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Ossification Regulation Of RNA Metabolic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Positive Regulation Of Osteoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Cell Differentiation Muscle Cell Differentiation Negative Regulation Of Gene Expression Muscle Tissue Development Negative Regulation Of Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Cardiac Septum Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Vasculogenesis Positive Regulation Of Ossification
Tagcloud ?		acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable src	a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Difference) ?		acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable src	a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Intersection) ?