GRIP1 and GRM2

Number of citations of the paper that reports this interaction (PubMedID 11891216)
0

Data Source:
BioGRID (pull down)

		GRIP1	GRM2
Description		glutamate receptor interacting protein 1	glutamate metabotropic receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways		Trafficking of GluR2-containing AMPA receptors	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH	31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1
Entrez ID		23426	2912
HPRD ID		19086	04977
Ensembl ID		ENSG00000155974	ENSG00000164082
Uniprot IDs		A0A8V8TLS6 Q9Y3R0	H7BXL3 Q14416
PDB IDs		2JIL	4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding	Membrane Plasma Membrane
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