GRB10 and IRS1

  • Number of citations of the paper that reports this interaction (PMID 8621530)
  • 14
  • Data Source:
  • BioGRID (pull down, affinity chromatography technology)

GRB10

IRS1

Gene Name growth factor receptor-bound protein 10 insulin receptor substrate 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 23512250)
  • Bone mineral density ( 22504420)
  • Fasting glucose-related traits (interaction with BMI) ( 22581228)
  • Systemic sclerosis ( 21779181)
Protein-Protein Interactions 30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17 73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID 2887 3667
HPRD ID 03312 00943
Ensembl ID ENSG00000106070 ENSG00000169047
Uniprot IDs Q13322 P35568
PDB IDs 1NRV 3HK0 1IRS 1K3A 1QQG 2Z8C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
becomes  carries  cytokine  driven  effector  emerging  exert  fashion  fos  grbir  homology  hybrid  insights  interacting  looked  member  nonreceptor  obscure  phosphorylated  pleckstrin  profoundly  ptks  subfamily  subset  suppresses  syk  tec  tips  turned 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Difference) ?
becomes  carries  cytokine  driven  effector  emerging  exert  fashion  fos  grbir  homology  hybrid  insights  interacting  looked  member  nonreceptor  obscure  pleckstrin  profoundly  ptks  subfamily  subset  suppresses  syk  tec  tips  turned 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Intersection) ?
phosphorylated