GRB10 and INSR

Number of citations of the paper that reports this interaction (PMID 7479769)
26

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		GRB10	INSR
Gene Name		growth factor receptor-bound protein 10	insulin receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola Endosome Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding	Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding PTB Domain Binding
	Biological Process	Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Negative Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Signal Transduction By Phosphorylation Male Sex Determination Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Protein Heterotetramerization Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus
Pathways		Signaling by SCF-KIT Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events SHC activation Signaling by Insulin receptor	Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events Insulin receptor recycling SHC activation Signaling by Insulin receptor
Drugs			Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Insulin, isophane
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250) Bone mineral density ( 22504420) Fasting glucose-related traits (interaction with BMI) ( 22581228) Systemic sclerosis ( 21779181)	Diabetic retinopathy ( 21441570) Height ( 20881960) Hypothyroidism ( 22493691) Polycystic ovary syndrome ( 22885925) Thyroid hormone levels ( 23408906) Urate levels ( 23263486)
Protein-Protein Interactions		30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17	77 interactors: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 ENPP1 FABP4 FRS2 GAB1 GNB2L1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B SYNCRIP TEAD1 VAV1 VAV3 YWHAB
Entrez ID		2887	3643
HPRD ID		03312	00975
Ensembl ID		ENSG00000106070	ENSG00000171105
Uniprot IDs		Q13322	P06213
PDB IDs		1NRV 3HK0	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3LOH 3W11 3W12 3W13 3W14 4IBM
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Phosphorylation Cellular Response To Organic Substance Intracellular Signal Transduction Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Positive Regulation Of Cell Motility Peptidyl-amino Acid Modification Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Component Movement Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Signaling Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Communication Cellular Response To Peptide Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Response To Hormone Regulation Of Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Kinase Activity Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Organonitrogen Compound Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Insulin Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Protein Phosphorylation Intracellular Signal Transduction Blood Coagulation Hemostasis Response To Insulin Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Wound Healing Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Growth Hormone Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Wounding Defense Response Signaling Immune Response-regulating Signaling Pathway
Tagcloud ?		becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Difference) ?		becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Intersection) ?