SNCG and GRK5

Number of citations of the paper that reports this interaction (PubMedID 10852916)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SNCG	GRK5
Description		synuclein gamma	G protein-coupled receptor kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Axon Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	Protein Binding Cuprous Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Chemical Synaptic Transmission Adult Locomotory Behavior Protein Secretion Regulation Of Dopamine Secretion Regulation Of Neurotransmitter Secretion Synaptic Vesicle Endocytosis Synapse Organization	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle
Pathways			G alpha (q) signalling events G alpha (s) signalling events
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: ADRB2 BUB1B GRK1 GRK5 GRK6 MAPK1 MAPK3 MAPK8 PCBP1 POT1 TERF1 TERF2IP	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6623	2869
HPRD ID		04297	02926
Ensembl ID		ENSG00000173267	ENSG00000198873
Uniprot IDs		F8W754 O76070 Q6FHG5	P34947
PDB IDs			4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Telomere Maintenance Protein Serine/threonine Kinase Activity Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Shelterin Complex G Protein-coupled Receptor Kinase Activity Protein Kinase Activity Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Kinase Activity Telomere Capping MAP Kinase Activity Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Stress-activated MAPK Cascade Positive Regulation Of Organelle Organization Stress-activated Protein Kinase Signaling Cascade RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Interleukin-34-mediated Signaling Pathway Protein Phosphorylation Negative Regulation Of Telomere Maintenance Beta-adrenergic Receptor Kinase Activity Regulation Of Golgi Inheritance Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Phosphorylation Regulation Of Organelle Organization Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Phosphatase Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Response To Amino Acid Starvation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Amino Acid Starvation Nucleobase-containing Compound Biosynthetic Process ATP Binding Regulation Of DNA Metabolic Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Telomeric D-loop Disassembly Bergmann Glial Cell Differentiation Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance	Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior
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