BDKRB2 and TPI1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		BDKRB2	TPI1
Description		bradykinin receptor B2	triosephosphate isomerase 1
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity	Triose-phosphate Isomerase Activity Protein Binding Methylglyoxal Synthase Activity Lyase Activity Isomerase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity
	Biological Process	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator	Glucose Metabolic Process Gluconeogenesis Glycolytic Process Methylglyoxal Biosynthetic Process Glycerol Catabolic Process Glyceraldehyde-3-phosphate Metabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process Canonical Glycolysis
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Glycolysis Gluconeogenesis
Drugs		Anatibant Icatibant Labradimil	Zinc N-Hydroxy-4-phosphonobutanamide 2-Phosphoglycolic Acid Phosphoglycolohydroxamic Acid 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid 5-fluorotryptophan 2-Carboxyethylphosphonic Acid tert-butanol Dihydroxyacetone phosphate 1,4-Dithiothreitol 3-phospho-D-glyceric acid 3-(BUTYLSULPHONYL)-PROPANOIC ACID Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)	Blood protein levels ( 30072576) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4	18 interacting genes: APP BDKRB2 CCL11 CDKN2A CEBPA CFL1 DDX24 EGFR HTR2C LIPT1 MAPK6 PCNA POT1 SETDB1 SP1 TERF1 UCHL5 YWHAQ
Entrez ID		624	7167
HPRD ID		00213	01833
Ensembl ID		ENSG00000168398	ENSG00000111669
Uniprot IDs		P30411	P60174 Q53HE2 V9HWK1
PDB IDs		7F2O 7F6H 7F6I	1HTI 1KLG 1KLU 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41 4POC 4POD 4UNK 4UNL 4ZVJ 6C2G 6D43 6NLH 6UP1 6UP5 6UP8 6UPF 7RDE 7SX1 7T0Q 7UXB 7UXV 9F69 9FFC
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling	Intracellular Signaling Cassette Regulation Of Cellular Response To Stress Intracellular Signal Transduction Telomere Maintenance Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Telomere Organization Shelterin Complex Regulation Of Developmental Process Regulation Of Proteolysis Positive Regulation Of Developmental Process Cellular Response To Hydrogen Peroxide Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Negative Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Maintenance Protein-containing Complex Regulation Of DNA Repair Regulation Of DNA Biosynthetic Process Chromatin Binding Morphogenesis Of An Epithelial Fold DNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Strand Elongation Positive Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Cellular Response To Chemical Stress Response To Hydrogen Peroxide Negative Regulation Of Cell Development Positive Regulation Of Metabolic Process Learning Or Memory Positive Regulation Of Chromosome Organization Cellular Response To Oxygen-containing Compound Cellular Response To Reactive Oxygen Species Regulation Of Telomere Maintenance Identical Protein Binding Negative Regulation Of Telomere Maintenance Via Telomerase Response To Amino Acid Telomere Maintenance Via Telomerase Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Cognition Positive Regulation Of Locomotion Positive Regulation Of Amyloid Precursor Protein Catabolic Process
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