BDKRB2 and TMEM11

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		BDKRB2	TMEM11
Description		bradykinin receptor B2	transmembrane protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Membrane
	Molecular Function	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator	Mitochondrion Organization Inner Mitochondrial Membrane Organization
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Cristae formation
Drugs		Anatibant Icatibant Labradimil
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)	Body mass index ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4	56 interacting genes: AQP6 ARL13B BDKRB2 BIK BNIP3 BNIP3L CCDC70 CCR4 CD79A CLDN7 CLN8 CREB3L1 CYB561 CYB5D2 DRD2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FATE1 FFAR2 GJB4 GORAB GPX8 KASH5 LEPROTL1 LMNA MRM1 MSMO1 MTIF3 MUC1 NDUFS3 OTX2 PDZK1IP1 PEX12 RETREG3 RIC3 RNASEH1 SCMH1 SGCB SLC10A6 SLC30A8 SUSD3 SUV39H1 TEX29 TMEM106C TMEM14B TMEM205 TMEM237 TMEM88 TMIE TMPRSS2 TNFSF14 YIPF6
Entrez ID		624	8834
HPRD ID		00213	12680
Ensembl ID		ENSG00000168398	ENSG00000178307
Uniprot IDs		P30411	P17152
PDB IDs		7F2O 7F6H 7F6I
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling	Membrane Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity
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