ANGPT2 and ITGA5

Number of citations of the paper that reports this interaction (PubMedID 16424009)
45

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ANGPT2	ITGA5
Description		angiopoietin 2	integrin subunit alpha 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Cell Projection	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Postsynaptic Membrane Anchoring Junction Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Receptor Ligand Activity	Virus Receptor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Blood Coagulation Response To Mechanical Stimulus Response To Glucose Gene Expression Negative Regulation Of Cell-substrate Adhesion Response To Activity Negative Regulation Of Angiogenesis Cell Differentiation Negative Regulation Of Blood Coagulation Animal Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Coagulation Negative Regulation Of Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development	Angiogenesis Formation Of Primary Germ Layer Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Tissue Development Positive Regulation Of Cell-substrate Adhesion Response To Muscle Activity CD40 Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Regulation Of Angiogenesis Symbiont Entry Into Host Cell Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis
Pathways		Tie2 Signaling	Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration GPER1 signaling Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Vanucizumab Faricimab	Resveratrol Tauroursodeoxycholic acid
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Dental caries (decayed and filled deciduous teeth) ( 31533690) Intraocular pressure ( 29617998 29785010 30054594) Metabolite levels ( 23823483) Response to cytidine analogues (gemcitabine) ( 24483146)	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK	32 interacting genes: ACKR5 ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL VTN
Entrez ID		285	3678
HPRD ID		03563	00627
Ensembl ID		ENSG00000091879	ENSG00000161638
Uniprot IDs		O15123	B2R627 P08648
PDB IDs		1Z3S 1Z3U 2GY7 4JZC 4ZFG 8VGP	3VI3 3VI4 4WJK 4WK0 4WK2 4WK4 7NWL 7NXD 9B9J 9B9K 9CKV
Enriched GO Terms of Interacting Partners?		Glomerulus Vasculature Development Tie Signaling Pathway Cell-substrate Adhesion Regulation Of Endothelial Cell Migration Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Vascular Permeability Angiogenesis Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Endothelial Cell Apoptotic Process Vasculature Development Regulation Of Locomotion Signaling Receptor Binding Microvillus Regulation Of Programmed Cell Death Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Endothelial Cell Migration Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Integrin Alpha5-beta1 Complex Positive Regulation Of Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Blood Vessel Development Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Endothelial Cell Proliferation Integrin Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell-substrate Adhesion Alphav-beta3 Integrin-vitronectin Complex Cellular Response To Cell-matrix Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Hemopoiesis Positive Regulation Of Angiogenesis Epithelial Cell Proliferation Positive Regulation Of Vasculature Development Positive Regulation Of Blood-brain Barrier Permeability	Cell Adhesion Integrin Binding Cell-substrate Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Migration Extracellular Matrix Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Response To Growth Factor Signal Transduction Cell Adhesion Mediated By Integrin Enzyme-linked Receptor Protein Signaling Pathway Cell Motility Extracellular Exosome Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Response To Wounding Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Blood Coagulation Cell Junction Organization Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Mesodermal Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Extracellular Region Regulation Of Cell-substrate Adhesion Regulation Of Anatomical Structure Morphogenesis Platelet Alpha Granule Membrane Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Wound Healing Regulation Of Cell Population Proliferation
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