ANGPT2 and ANXA7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ANGPT2	ANXA7
Description		angiopoietin 2	annexin A7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Cell Projection	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Chromaffin Granule Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Receptor Ligand Activity	Phosphatidylserine Binding RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Blood Coagulation Response To Mechanical Stimulus Response To Glucose Gene Expression Negative Regulation Of Cell-substrate Adhesion Response To Activity Negative Regulation Of Angiogenesis Cell Differentiation Negative Regulation Of Blood Coagulation Animal Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Coagulation Negative Regulation Of Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development	Autophagy Negative Regulation Of Gene Expression Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion Response To Phorbol 13-acetate 12-myristate
Pathways		Tie2 Signaling
Drugs		Vanucizumab Faricimab
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Dental caries (decayed and filled deciduous teeth) ( 31533690) Intraocular pressure ( 29617998 29785010 30054594) Metabolite levels ( 23823483) Response to cytidine analogues (gemcitabine) ( 24483146)	Copper levels ( 26025379)
Interacting Genes		6 interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK	109 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CREBBP CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 HUNK INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OGT OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		285	310
HPRD ID		03563	01720
Ensembl ID		ENSG00000091879	ENSG00000138279
Uniprot IDs		O15123	B2R657 P20073
PDB IDs		1Z3S 1Z3U 2GY7 4JZC 4ZFG 8VGP	8W5S
Enriched GO Terms of Interacting Partners?		Glomerulus Vasculature Development Tie Signaling Pathway Cell-substrate Adhesion Regulation Of Endothelial Cell Migration Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Vascular Permeability Angiogenesis Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Endothelial Cell Apoptotic Process Vasculature Development Regulation Of Locomotion Signaling Receptor Binding Microvillus Regulation Of Programmed Cell Death Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Endothelial Cell Migration Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Integrin Alpha5-beta1 Complex Positive Regulation Of Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Blood Vessel Development Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Endothelial Cell Proliferation Integrin Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell-substrate Adhesion Alphav-beta3 Integrin-vitronectin Complex Cellular Response To Cell-matrix Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Hemopoiesis Positive Regulation Of Angiogenesis Epithelial Cell Proliferation Positive Regulation Of Vasculature Development Positive Regulation Of Blood-brain Barrier Permeability	TORC1 Signaling Extracellular Exosome TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Metabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Cytoplasm Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Extracellular Matrix Positive Regulation Of Biosynthetic Process Positive Regulation Of TOR Signaling Developmental Process Regulation Of Metabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Protein Deubiquitination Cellular Response To Nutrient Levels Regulation Of Proteolysis Histone H3T6 Kinase Activity Structural Constituent Of Cytoskeleton Positive Regulation Of Protein Metabolic Process Platelet Alpha Granule Lumen Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Blood Microparticle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Cytoplasmic Translation Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Matrix Response To Interleukin-1 Response To Cytokine Regulation Of Protein Localization Negative Regulation Of Signal Transduction Calyx Of Held Negative Regulation Of Translational Initiation Protein Kinase C Signaling Proteasomal Protein Catabolic Process
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