ZSCAN1 and RFC1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZSCAN1	RFC1
Description		zinc finger and SCAN domain containing 1	replication factor C subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Elg1 RFC-like Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication DNA Repair Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		40 interacting genes: ANKRD55 APP ASH2L ATXN1 CDC5L CDK6 CNOT6L ERCC3 FXR2 GOPC GTF2E1 GTF2H1 HOPX INSM2 MED21 MED31 MED7 NFYC NPAS2 PLRG1 POLR2B POLR2D POLR2E PPARG PPL RFC1 SH2D2A SNW1 SSX3 SSX5 TAF7 TBX20 TIMELESS TRIM31 TTF2 ZKSCAN5 ZNF263 ZNF396 ZNF407 ZSCAN22	20 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC USP7 YWHAQ ZSCAN1
Entrez ID		284312	5981
HPRD ID		15897	00024
Ensembl ID		ENSG00000152467	ENSG00000035928
Uniprot IDs		Q8NBB4	P35251
PDB IDs			2EBU 2K6G 2K7F 6VVO
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA Binding Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Initiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process DNA-templated Transcription Nucleic Acid Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II, Core Complex Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of RNA Metabolic Process Transcription Preinitiation Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Core Mediator Complex Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome DNA-directed RNA Polymerase Activity Nucleoplasm Transcription Factor TFIID Complex Macromolecule Biosynthetic Process	DNA Damage Response Positive Regulation Of DNA-directed DNA Polymerase Activity Enzyme Binding Nucleoplasm Nucleus Cellular Response To Stress Response To Xenobiotic Stimulus Chromatin Binding Cyclin D1-CDK4 Complex P53 Binding Protein-containing Complex Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Response To Steroid Hormone Symbiont-mediated Disruption Of Host Cell PML Body Transcription Regulator Complex Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Transcription Cis-regulatory Region Binding Response To Tumor Necrosis Factor DNA Replication Factor C Complex Histone Deacetylase Binding Regulation Of Metabolic Process Response To Glucocorticoid Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Positive Regulation Of DNA Biosynthetic Process DNA Repair Condensed Nuclear Chromosome Ctf18 RFC-like Complex Response To Corticosteroid Response To UV Animal Organ Regeneration DNA Clamp Loader Activity Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Vitamin Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Suppression Of Viral Transcription Chromosome
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