ZSCAN1 and TIMELESS

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZSCAN1	TIMELESS
Description		zinc finger and SCAN domain containing 1	timeless circadian regulator
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Chromosome Replication Fork Protection Complex Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Enzyme Activator Activity Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair DNA Damage Response Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Replication Fork Processing Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair
Pathways			Processing of DNA double-strand break ends
Drugs
Diseases
GWAS			Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ANKRD55 APP ASH2L ATXN1 CDC5L CDK6 CNOT6L ERCC3 FXR2 GOPC GTF2E1 GTF2H1 HOPX INSM2 MED21 MED31 MED7 NFYC NPAS2 PLRG1 POLR2B POLR2D POLR2E PPARG PPL RFC1 SH2D2A SNW1 SSX3 SSX5 TAF7 TBX20 TIMELESS TRIM31 TTF2 ZKSCAN5 ZNF263 ZNF396 ZNF407 ZSCAN22	12 interacting genes: CHEK1 CLSPN CRY1 CRY2 PCBD1 PER1 PER2 PLK1 TF TIPIN WEE2-AS1 ZSCAN1
Entrez ID		284312	8914
HPRD ID		15897	04864
Ensembl ID		ENSG00000152467	ENSG00000111602
Uniprot IDs		Q8NBB4	Q9UNS1
PDB IDs			4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA Binding Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Initiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process DNA-templated Transcription Nucleic Acid Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II, Core Complex Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of RNA Metabolic Process Transcription Preinitiation Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Core Mediator Complex Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome DNA-directed RNA Polymerase Activity Nucleoplasm Transcription Factor TFIID Complex Macromolecule Biosynthetic Process	Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Signal Transduction In Response To DNA Damage Negative Regulation Of Circadian Rhythm Mitotic DNA Damage Checkpoint Signaling Circadian Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity DNA Damage Checkpoint Signaling Regulation Of Circadian Rhythm Cry-Per Complex Mitotic G2 DNA Damage Checkpoint Signaling Response To Light Stimulus Circadian Rhythm Negative Regulation Of Glucocorticoid Secretion Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic G2/M Transition Checkpoint DNA Damage Response Response To Blue Light Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Photoreceptor Activity Anaphase-promoting Complex Binding Rhythmic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic Nuclear Membrane Disassembly Negative Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Kinase Binding Nuclear Membrane Disassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Membrane Disassembly Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Metabolic Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Process DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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