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ZSCAN1 and ASH2L
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
ZSCAN1
ASH2L
Gene Name
zinc finger and SCAN domain containing 1
ash2 (absent, small, or homeotic)-like (Drosophila)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
Set1C/COMPASS Complex
Molecular Function
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
DNA Binding
Transcription Coactivator Activity
Metal Ion Binding
DNA Binding
Protein Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Transcription Regulatory Region DNA Binding
Metal Ion Binding
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Proliferation
Hemopoiesis
Response To Estrogen
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3-K4 Methylation
Pathways
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
formation of the beta-catenin:TCF transactivating complex
PKMTs methylate histone lysines
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
Chromatin modifying enzymes
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Menopause (age at onset) (
22267201
)
Protein-Protein Interactions
38 interactors:
ANKRD55
APP
ASH2L
ATXN1
CDC5L
CDK4
CDK6
CNOT6L
ERCC3
FXR2
GOPC
GTF2E1
GTF2H1
HOPX
INSM2
MED21
MED31
MED7
NPAS2
PLRG1
POLR2B
POLR2D
POLR2E
PPARG
PPL
RFC1
SNW1
SSX3
SSX5
TAF7
TBX20
TIMELESS
TRIM31
TTF2
ZKSCAN5
ZNF263
ZNF396
ZNF407
22 interactors:
BARD1
BRCA1
CHD8
CTNNB1
DPY30
EP300
HCFC2
HIST1H3A
HIST3H3
KMT2A
KMT2D
MEN1
PPP1CC
PRMT1
SMAD9
SMURF1
SMURF2
TGFBR1
TP53
UNC119
WWP1
ZSCAN1
Entrez ID
284312
9070
HPRD ID
15897
05309
Ensembl ID
ENSG00000152467
ENSG00000129691
Uniprot IDs
Q8NBB4
B4DPT1
F5H8F7
Q9UBL3
PDB IDs
3RSN
3S32
3TOJ
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Gene Expression
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
DNA-templated Transcription, Initiation
Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Viral Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription From RNA Polymerase II Promoter
MRNA Processing
Negative Regulation Of Gene Expression
RNA Processing
Positive Regulation Of Cellular Biosynthetic Process
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Viral Transcription
MRNA Metabolic Process
Regulation Of Cellular Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Positive Regulation Of Viral Process
7-methylguanosine RNA Capping
DNA-templated Transcription, Elongation
Regulation Of Viral Process
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of RNA Biosynthetic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Negative Regulation Of Gene Expression
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Histone Modification
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Chromatin Organization
Negative Regulation Of Biosynthetic Process
Chromosome Organization
Positive Regulation Of Histone Methylation
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cellular Metabolic Process
Cellular Protein Modification Process
Histone Methylation
Regulation Of Histone Modification
Positive Regulation Of Transcription, DNA-templated
Regulation Of Histone Methylation
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Signal Transduction
Chordate Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
Positive Regulation Of Macromolecule Biosynthetic Process
Embryo Development
Positive Regulation Of Gene Expression
Protein Methylation
Negative Regulation Of Signaling
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Histone H3-K4 Methylation
Nucleobase-containing Compound Metabolic Process
Chromatin Modification
Regulation Of Chromosome Organization
Histone Modification
Heterocycle Metabolic Process
Tagcloud
?
acidic
allosterically
box
compass
composed
concave
dpy30
erythroid
forming
heterodimer
interface
kmt2
lysine
methyltransferase
methyltransferases
mll1
mutational
rbbp5
referred
ryanodine
set1
spia
spry
stimulates
switch
trithorax
trxg
wdr5
wrad
Tagcloud (Difference)
?
acidic
allosterically
box
compass
composed
concave
dpy30
erythroid
forming
heterodimer
interface
kmt2
lysine
methyltransferase
methyltransferases
mll1
mutational
rbbp5
referred
ryanodine
set1
spia
spry
stimulates
switch
trithorax
trxg
wdr5
wrad
Tagcloud (Intersection)
?