ZSCAN1 and GTF2H1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZSCAN1	GTF2H1
Gene Name		zinc finger and SCAN domain containing 1	general transcription factor IIH, polypeptide 1, 62kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Coactivator Activity Metal Ion Binding	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways			RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)
Protein-Protein Interactions		38 interactors: ANKRD55 APP ASH2L ATXN1 CDC5L CDK4 CDK6 CNOT6L ERCC3 FXR2 GOPC GTF2E1 GTF2H1 HOPX INSM2 MED21 MED31 MED7 NPAS2 PLRG1 POLR2B POLR2D POLR2E PPARG PPL RFC1 SNW1 SSX3 SSX5 TAF7 TBX20 TIMELESS TRIM31 TTF2 ZKSCAN5 ZNF263 ZNF396 ZNF407	42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1
Entrez ID		284312	2965
HPRD ID		15897	01807
Ensembl ID		ENSG00000152467	ENSG00000110768
Uniprot IDs		Q8NBB4	P32780
PDB IDs			1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter MRNA Processing Negative Regulation Of Gene Expression RNA Processing Positive Regulation Of Cellular Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription MRNA Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Viral Process 7-methylguanosine RNA Capping DNA-templated Transcription, Elongation Regulation Of Viral Process Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process	Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress
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