GTF2H1 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 10777215)
0

Data Source:
HPRD (in vivo, in vitro)

		GTF2H1	ATF7IP
Description		general transcription factor IIH subunit 1	activating transcription factor 7 interacting protein
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Chromatin Binding Protein Binding Nuclear Thyroid Hormone Receptor Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Amyloid A serum levels ( 21124955) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944 33031748) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		2965	55729
HPRD ID		01807	09811
Ensembl ID		ENSG00000110768	ENSG00000171681
Uniprot IDs		A0A384MTQ8 P32780	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7AD8 7BUL 7DTI 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	2RPQ
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription Factor TFIIH Holo Complex Transcription Factor TFIIH Core Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Nucleoplasm Nucleic Acid Metabolic Process DNA-templated Transcription Initiation CAK-ERCC2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Nucleus Nucleobase-containing Compound Biosynthetic Process Damaged DNA Binding DNA Repair DNA Damage Response Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFIIK Complex Single-stranded DNA Binding DNA Binding UV Protection Transcription Factor TFIID Complex DNA Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Complex Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Response To Radiation Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription-coupled Nucleotide-excision Repair	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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