GTF2H1 and ERCC2

Number of citations of the paper that reports this interaction (PubMedID 9130708)
32

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GTF2H1	ERCC2
Description		general transcription factor IIH subunit 1	ERCC excision repair 2, TFIIH core complex helicase subunit
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Cytoplasm Spindle Cytosol Cytoskeleton CAK-ERCC2 Complex MMXD Complex
	Molecular Function	Chromatin Binding Protein Binding Nuclear Thyroid Hormone Receptor Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Response To Hypoxia In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Apoptotic Process DNA Damage Response Response To Oxidative Stress Chromosome Segregation Determination Of Adult Lifespan Response To UV UV Protection Post-embryonic Development Spinal Cord Development Hair Cycle Process Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Ribosomal Small Subunit Biogenesis Erythrocyte Maturation Skin Development Positive Regulation Of Mitotic Recombination Insulin-like Growth Factor Receptor Signaling Pathway Embryonic Organ Development Hair Follicle Maturation Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Proliferation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript Cytosolic iron-sulfur cluster assembly NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Amyloid A serum levels ( 21124955) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944 33031748) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Lung Cancer (DNA repair capacity) ( 23108145) Sleep (1/2-day periodicity) ( 33075057)
Interacting Genes		46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	16 interacting genes: AR CDK1 CDK7 ERCC3 ERCC5 GTF2E1 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 MTDH RAD51 RAD52 TP53 TRIM25
Entrez ID		2965	2068
HPRD ID		01807	00530
Ensembl ID		ENSG00000110768	ENSG00000104884
Uniprot IDs		A0A384MTQ8 P32780	P18074
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7AD8 7BUL 7DTI 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 6TUN 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription Factor TFIIH Holo Complex Transcription Factor TFIIH Core Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Nucleoplasm Nucleic Acid Metabolic Process DNA-templated Transcription Initiation CAK-ERCC2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Nucleus Nucleobase-containing Compound Biosynthetic Process Damaged DNA Binding DNA Repair DNA Damage Response Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFIIK Complex Single-stranded DNA Binding DNA Binding UV Protection Transcription Factor TFIID Complex DNA Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Complex Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Response To Radiation Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription-coupled Nucleotide-excision Repair	Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleotide-excision Repair DNA Repair DNA-templated Transcription DNA Metabolic Process DNA Damage Response Nucleic Acid Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Transcription Factor TFIID Complex RNA Metabolic Process Macromolecule Metabolic Process Response To Stress Nucleoplasm Core TFIIH Complex Portion Of Holo TFIIH Complex Nucleus RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombinase Assembly Response To UV Response To Oxidative Stress Regulation Of Primary Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Response To Radiation Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Transcription-coupled Nucleotide-excision Repair Chromatin Binding Transcription Preinitiation Complex Regulation Of Macromolecule Metabolic Process Response To UV-C Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Single-stranded DNA Binding Mitotic Recombination Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Activity
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