GTF2H1 and KIF13A

Number of citations of the paper that reports this interaction (PubMedID 10777215)
0

Data Source:
HPRD (in vitro, in vivo)

		GTF2H1	KIF13A
Description		general transcription factor IIH subunit 1	kinesin family member 13A
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Centrosome Cytoskeleton Kinesin Complex Microtubule Endosome Membrane Membrane Midbody Trans-Golgi Network Membrane
	Molecular Function	Chromatin Binding Protein Binding Nuclear Thyroid Hormone Receptor Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription	Intracellular Protein Transport Microtubule-based Movement Endosome To Lysosome Transport Protein Transport Melanosome Organization Regulation Of Cytokinesis Vesicle Cargo Loading Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization Cell Division Plus-end-directed Vesicle Transport Along Microtubule
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Amyloid A serum levels ( 21124955) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944 33031748) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)	Height ( 18391951) Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	9 interacting genes: AP1B1 AP1G1 AP1M1 ATF7IP DNAAF6 GTF2H1 PPP1CA TRIM55 USP7
Entrez ID		2965	63971
HPRD ID		01807	09256
Ensembl ID		ENSG00000110768	ENSG00000137177
Uniprot IDs		A0A384MTQ8 P32780	Q9H1H9
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7AD8 7BUL 7DTI 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription Factor TFIIH Holo Complex Transcription Factor TFIIH Core Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Nucleoplasm Nucleic Acid Metabolic Process DNA-templated Transcription Initiation CAK-ERCC2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Nucleus Nucleobase-containing Compound Biosynthetic Process Damaged DNA Binding DNA Repair DNA Damage Response Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFIIK Complex Single-stranded DNA Binding DNA Binding UV Protection Transcription Factor TFIID Complex DNA Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Complex Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Response To Radiation Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription-coupled Nucleotide-excision Repair	AP-1 Adaptor Complex Melanosome Assembly Platelet Dense Granule Organization Melanosome Organization Clathrin-coated Vesicle Membrane Pigment Granule Organization Basolateral Protein Secretion Secretory Granule Organization Endosome To Melanosome Transport Clathrin Adaptor Complex Trans-Golgi Network Membrane Clathrin Adaptor Activity Cytoplasmic Vesicle Membrane Membrane Coat Nucleotide-excision Repair Organelle Assembly Vesicle Organization Early Endosome Clathrin-coated Vesicle Lysosomal Membrane Synaptic Vesicle Budding From Endosome RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Glucose Metabolic Process Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Symbiont-mediated Disruption Of Host Cell PML Body Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Regulation Of Circadian Rhythm Positive Regulation Of Natural Killer Cell Degranulation DNA Repair Intracellular Protein Transport Glycogen Granule Regulation Of Establishment Of Protein Localization To Telomere PTW/PP1 Phosphatase Complex Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Interleukin-4 Production Diapedesis Negative Regulation Of Gene Expression, Epigenetic RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process
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