GTF2H1 and ERCC4

Number of citations of the paper that reports this interaction (PubMedID 11259578)
68

Data Source:
HPRD (in vitro)

		GTF2H1	ERCC4
Description		general transcription factor IIH subunit 1	ERCC excision repair 4, endonuclease catalytic subunit
Image
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome ERCC4-ERCC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Nuclear Thyroid Hormone Receptor Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Telomerase Inhibitor Activity Hydrolase Activity Identical Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Cellular Response To UV Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Amyloid A serum levels ( 21124955) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944 33031748) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)	Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 28991256 30285260 25056061) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)
Interacting Genes		46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	12 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1
Entrez ID		2965	2072
HPRD ID		01807	00594
Ensembl ID		ENSG00000110768	ENSG00000175595
Uniprot IDs		A0A384MTQ8 P32780	A0A1W1GSK9 A0A804HKF9 B4DXD8 Q92889
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7AD8 7BUL 7DTI 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription Factor TFIIH Holo Complex Transcription Factor TFIIH Core Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Nucleoplasm Nucleic Acid Metabolic Process DNA-templated Transcription Initiation CAK-ERCC2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Nucleus Nucleobase-containing Compound Biosynthetic Process Damaged DNA Binding DNA Repair DNA Damage Response Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFIIK Complex Single-stranded DNA Binding DNA Binding UV Protection Transcription Factor TFIID Complex DNA Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Complex Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Response To Radiation Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription-coupled Nucleotide-excision Repair	Nucleotide-excision Repair DNA Repair Positive Regulation Of T-circle Formation DNA Metabolic Process Double-strand Break Repair Telomere Maintenance DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair T-circle Formation Damaged DNA Binding DNA Double-strand Break Processing Single-stranded DNA Binding Slx1-Slx4 Complex Cellular Response To Stress Negative Regulation Of Telomere Maintenance Chromosome Organization ERCC4-ERCC1 Complex Organelle Organization Chromosome, Telomeric Region Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly DNA Replication Factor A Complex Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Nucleobase-containing Compound Metabolic Process Mitotic Recombination Negative Regulation Of DNA Metabolic Process DNA Replication Nucleus Nuclear Thyroid Hormone Receptor Binding Mismatch Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleoplasm Telomere Maintenance Via Telomere Lengthening Base-excision Repair Response To Stress Interstrand Cross-link Repair Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Via Single-strand Annealing
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