GTF2H1 and TRIOBP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GTF2H1	TRIOBP
Description		general transcription factor IIH subunit 1	TRIO and F-actin binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Centrosome Cytoskeleton Focal Adhesion Actin Cytoskeleton Midbody Stereocilium Base
	Molecular Function	Chromatin Binding Protein Binding Nuclear Thyroid Hormone Receptor Binding	Actin Binding Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription	Sensory Perception Of Sound Actin Modification Barbed-end Actin Filament Capping Cell Division Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Amyloid A serum levels ( 21124955) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944 33031748) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)	Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096 34108613) Age-related hearing impairment (low/mid frequency) ( 31645637) Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lateral ventricular volume in normal aging ( 30258056) Optic cup area ( 28073927 25631615) Pulse pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	11 interacting genes: DSCR9 FXR1 FXR2 GTF2H1 HECTD3 IKBKG LCOR PLK1 POLR1C TSC1 VIM
Entrez ID		2965	11078
HPRD ID		01807	11028
Ensembl ID		ENSG00000110768	ENSG00000100106
Uniprot IDs		A0A384MTQ8 P32780	Q9H2D6
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7AD8 7BUL 7DTI 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription Factor TFIIH Holo Complex Transcription Factor TFIIH Core Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Nucleoplasm Nucleic Acid Metabolic Process DNA-templated Transcription Initiation CAK-ERCC2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Nucleus Nucleobase-containing Compound Biosynthetic Process Damaged DNA Binding DNA Repair DNA Damage Response Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFIIK Complex Single-stranded DNA Binding DNA Binding UV Protection Transcription Factor TFIID Complex DNA Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Complex Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Response To Radiation Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription-coupled Nucleotide-excision Repair	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Transcription By RNA Polymerase I Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Catabolic Process Memory T Cell Differentiation Regulation Of Neuronal Synaptic Plasticity
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