ANGPT1 and ITGA5

Number of citations of the paper that reports this interaction (PMID 15781448)
12

Data Source:
HPRD (in vitro)

		ANGPT1	ITGA5
Gene Name		angiopoietin 1	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Membrane Raft Extracellular Vesicular Exosome	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Receptor Tyrosine Kinase Binding	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Cell Adhesion Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Satellite Cell Proliferation Hemopoiesis Cell Differentiation Heparin Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ANGPT2 ITGA5 TEK	24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC
Entrez ID		284	3678
HPRD ID		03392	00627
Ensembl ID		ENSG00000154188	ENSG00000161638
Uniprot IDs		B4DTQ9 E7ERK4 Q15389	P08648
PDB IDs		4EPU 4JYO 4K0V	3VI3 3VI4
Enriched GO Terms of Interacting Partners?		Tie Signaling Pathway Regulation Of Cell-substrate Adhesion Leukocyte Migration Angiogenesis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Blood Vessel Development Vasculature Development Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Organ Regeneration Negative Regulation Of Angiogenesis Cell Migration Cardiovascular System Development Cell Motility Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Epithelial Cell Migration Negative Regulation Of Positive Chemotaxis Locomotion Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Regulation Of Angiogenesis Response To Hypoxia Cell Development Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Cellular Amino Acid Metabolic Process Cell-cell Adhesion Mediated By Integrin Anatomical Structure Morphogenesis Regulation Of Cellular Ketone Metabolic Process Single Organismal Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Regulation Of Cytokine Secretion Involved In Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Actin Cytoskeleton Reorganization	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction
Tagcloud ?		clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity
Tagcloud (Difference) ?		clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity
Tagcloud (Intersection) ?