ANGPT1 and ITGA5

Number of citations of the paper that reports this interaction (PubMedID 15781448)
0

Data Source:
HPRD (in vitro)

		ANGPT1	ITGA5
Description		angiopoietin 1	integrin subunit alpha 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Extracellular Matrix Membrane Raft Extracellular Exosome	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Postsynaptic Membrane Anchoring Junction Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Receptor Ligand Activity	Virus Receptor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Angiogenesis Blood Vessel Development In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Skeletal Muscle Satellite Cell Proliferation Hemopoiesis Cell Differentiation Negative Regulation Of Blood Coagulation Heparin Proteoglycan Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Coagulation Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Formation Of Primary Germ Layer Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Tissue Development Positive Regulation Of Cell-substrate Adhesion Response To Muscle Activity CD40 Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Regulation Of Angiogenesis Symbiont Entry Into Host Cell Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade	Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration GPER1 signaling Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Resveratrol Tauroursodeoxycholic acid
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Face memory ( 31596458) Fractional exhaled nitric oxide (childhood) ( 24315451) Glaucoma ( 30054594 31959993) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (primary open-angle) ( 29891935 33627673) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antiglaucoma preparations and miotics) ( 31015401) Periodontitis (stage III/IV grade C) ( 33745150) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: ANGPT2 FBLN7 ITGA5 SNCA TEK TIE1	32 interacting genes: ACKR5 ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL VTN
Entrez ID		284	3678
HPRD ID		03392	00627
Ensembl ID		ENSG00000154188	ENSG00000161638
Uniprot IDs		B4DTQ9 Q15389	B2R627 P08648
PDB IDs		4EPU 4JYO 4K0V	3VI3 3VI4 4WJK 4WK0 4WK2 4WK4 7NWL 7NXD 9B9J 9B9K 9CKV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Tie Signaling Pathway Glomerulus Vasculature Development Angiogenesis Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Locomotion Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Blood Vessel Development Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Activity Vasculature Development Regulation Of Cell Motility Negative Regulation Of Positive Chemotaxis Response To Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Focal Adhesion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Branching Involved In Lymph Vessel Morphogenesis Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Integrin Alpha5-beta1 Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-substrate Adhesion Calcium Ion Binding Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Alphav-beta3 Integrin-vitronectin Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Proliferation Cell-substrate Adhesion Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process	Cell Adhesion Integrin Binding Cell-substrate Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Migration Extracellular Matrix Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Response To Growth Factor Signal Transduction Cell Adhesion Mediated By Integrin Enzyme-linked Receptor Protein Signaling Pathway Cell Motility Extracellular Exosome Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Response To Wounding Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Blood Coagulation Cell Junction Organization Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Mesodermal Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Extracellular Region Regulation Of Cell-substrate Adhesion Regulation Of Anatomical Structure Morphogenesis Platelet Alpha Granule Membrane Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Wound Healing Regulation Of Cell Population Proliferation
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