ANGPT1 and TIE1

Number of citations of the paper that reports this interaction (PubMedID 18593464)
70

Data Source:
BioGRID (unspecified method)

		ANGPT1	TIE1
Description		angiopoietin 1	tyrosine kinase with immunoglobulin like and EGF like domains 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Extracellular Matrix Membrane Raft Extracellular Exosome	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Receptor Ligand Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Angiogenesis Blood Vessel Development In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Skeletal Muscle Satellite Cell Proliferation Hemopoiesis Cell Differentiation Negative Regulation Of Blood Coagulation Heparin Proteoglycan Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Coagulation Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Tissue Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Face memory ( 31596458) Fractional exhaled nitric oxide (childhood) ( 24315451) Glaucoma ( 30054594 31959993) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (primary open-angle) ( 29891935 33627673) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antiglaucoma preparations and miotics) ( 31015401) Periodontitis (stage III/IV grade C) ( 33745150) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: ANGPT2 FBLN7 ITGA5 SNCA TEK TIE1	13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1
Entrez ID		284	7075
HPRD ID		03392	02572
Ensembl ID		ENSG00000154188	ENSG00000066056
Uniprot IDs		B4DTQ9 Q15389	B4DTW8 P35590
PDB IDs		4EPU 4JYO 4K0V	5N06
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Tie Signaling Pathway Glomerulus Vasculature Development Angiogenesis Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Locomotion Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Blood Vessel Development Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Activity Vasculature Development Regulation Of Cell Motility Negative Regulation Of Positive Chemotaxis Response To Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Focal Adhesion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Branching Involved In Lymph Vessel Morphogenesis Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Integrin Alpha5-beta1 Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-substrate Adhesion Calcium Ion Binding Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Alphav-beta3 Integrin-vitronectin Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Proliferation Cell-substrate Adhesion Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process	Glomerulus Vasculature Development Tie Signaling Pathway Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Glycerolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Endothelial Cell Migration Phosphatidylinositol Metabolic Process Insulin Receptor Binding Regulation Of Intracellular Protein Transport Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Production Cell Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Hemopoiesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-substrate Adhesion Positive Regulation Of D-glucose Import Glycerophospholipid Biosynthetic Process Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Biosynthetic Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cell Migration Regulation Of Vascular Permeability Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Motility Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Locomotion Vasculature Development Glycerophospholipid Metabolic Process Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Vascular Process In Circulatory System Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade
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