ANGPT1 and TEK

Number of citations of the paper that reports this interaction (PMID 8980224)
416

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		ANGPT1	TEK
Gene Name		angiopoietin 1	TEK tyrosine kinase, endothelial
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Membrane Raft Extracellular Vesicular Exosome	Stress Fiber Extracellular Region Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Tyrosine Kinase Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Protein Binding ATP Binding Growth Factor Binding
	Biological Process	In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Cell Adhesion Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Satellite Cell Proliferation Hemopoiesis Cell Differentiation Heparin Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Cell-matrix Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Organ Regeneration Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Protein Oligomerization Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ANGPT2 ITGA5 TEK	20 interactors: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP DOK2 DOK4 GRB14 GRB2 GRB7 IKBKG PIK3R1 PTPN11 PTPRB SHC1 SOCS1 STAT5A STAT5B TIE1 TNIP2
Entrez ID		284	7010
HPRD ID		03392	02571
Ensembl ID		ENSG00000154188	ENSG00000120156
Uniprot IDs		B4DTQ9 E7ERK4 Q15389	Q02763 Q59HG2
PDB IDs		4EPU 4JYO 4K0V	1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V
Enriched GO Terms of Interacting Partners?		Tie Signaling Pathway Regulation Of Cell-substrate Adhesion Leukocyte Migration Angiogenesis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Blood Vessel Development Vasculature Development Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Organ Regeneration Negative Regulation Of Angiogenesis Cell Migration Cardiovascular System Development Cell Motility Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Epithelial Cell Migration Negative Regulation Of Positive Chemotaxis Locomotion Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Regulation Of Angiogenesis Response To Hypoxia Cell Development Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Cellular Amino Acid Metabolic Process Cell-cell Adhesion Mediated By Integrin Anatomical Structure Morphogenesis Regulation Of Cellular Ketone Metabolic Process Single Organismal Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Regulation Of Cytokine Secretion Involved In Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Actin Cytoskeleton Reorganization	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Body Fluid Levels Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Blood Coagulation Hemostasis Immune System Process Signal Transduction Wound Healing Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Wounding Cellular Response To Stimulus Cell Migration Regulation Of Immune Response Response To Stimulus Cell Motility Locomotion Response To Stress Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Peptide Movement Of Cell Or Subcellular Component Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Signal Transduction Response To Growth Hormone Regulation Of Innate Immune Response Intracellular Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Regulation Of Kinase Activity Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Development Of Secondary Male Sexual Characteristics JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity	amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk
Tagcloud (Difference) ?		clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity	amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk
Tagcloud (Intersection) ?