ANGPT1 and ANGPT2

Number of citations of the paper that reports this interaction (PMID 9204896)
412

Data Source:
HPRD (in vitro, in vivo)

		ANGPT1	ANGPT2
Gene Name		angiopoietin 1	angiopoietin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Projection
	Molecular Function	Receptor Tyrosine Kinase Binding	Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Cell Adhesion Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Satellite Cell Proliferation Hemopoiesis Cell Differentiation Heparin Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Blood Coagulation Response To Radiation Response To Mechanical Stimulus Response To Glucose Negative Regulation Of Cell-substrate Adhesion Response To Organic Cyclic Compound Response To Activity Negative Regulation Of Angiogenesis Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Leukocyte Migration Negative Regulation Of Positive Chemotaxis Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ANGPT2 ITGA5 TEK	5 interactors: ANGPT1 ANXA7 CDKN1A CSNK2B TEK
Entrez ID		284	285
HPRD ID		03392	03563
Ensembl ID		ENSG00000154188	ENSG00000091879
Uniprot IDs		B4DTQ9 E7ERK4 Q15389	O15123
PDB IDs		4EPU 4JYO 4K0V	1Z3S 1Z3U 2GY7 4JZC
Enriched GO Terms of Interacting Partners?		Tie Signaling Pathway Regulation Of Cell-substrate Adhesion Leukocyte Migration Angiogenesis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Blood Vessel Development Vasculature Development Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Organ Regeneration Negative Regulation Of Angiogenesis Cell Migration Cardiovascular System Development Cell Motility Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Epithelial Cell Migration Negative Regulation Of Positive Chemotaxis Locomotion Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Regulation Of Angiogenesis Response To Hypoxia Cell Development Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Cellular Amino Acid Metabolic Process Cell-cell Adhesion Mediated By Integrin Anatomical Structure Morphogenesis Regulation Of Cellular Ketone Metabolic Process Single Organismal Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Regulation Of Cytokine Secretion Involved In Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Actin Cytoskeleton Reorganization	Tie Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Cytokine Secretion Involved In Immune Response Regulation Of Epithelial Cell Migration Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Phosphorylation Regulation Of Protein Localization To Nucleus Regulation Of Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Phosphorylation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Regulation Of Intracellular Protein Transport Regulation Of Vascular Permeability Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Phosphorylation Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Hemostasis Regulation Of Intracellular Transport Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Organ Regeneration Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Transferase Activity Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Body Fluid Levels Regulation Of Cell Migration Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Peptidyl-serine Phosphorylation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Cellular Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade
Tagcloud ?		clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity	clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		clonality clones comings depicting deregulated engrafted gammaretroviral genotoxicity gv harboring hematopoiesis hsc hscs il2rg immunodeficient insertion insertional integrating integrations leukemogenesis ltr nsg overrepresentation resembling transplanted underscore utilizing vicinity