ANGPT1 and ANGPT2

Number of citations: 0 (PubMedID 9204896)
Data Source: HPRD (in vivo, in vitro)

		ANGPT1	ANGPT2
Name		angiopoietin 1	angiopoietin 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Extracellular Matrix Membrane Raft Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Cell Projection
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Receptor Ligand Activity	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Blood Vessel Development In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Skeletal Muscle Satellite Cell Proliferation Hemopoiesis Cell Differentiation Negative Regulation Of Blood Coagulation Heparin Proteoglycan Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Coagulation Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Blood Coagulation Response To Mechanical Stimulus Response To Glucose Gene Expression Negative Regulation Of Cell-substrate Adhesion Response To Activity Negative Regulation Of Angiogenesis Cell Differentiation Negative Regulation Of Blood Coagulation Animal Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Coagulation Negative Regulation Of Positive Chemotaxis Positive Regulation Of Multicellular Organismal Process Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade	Tie2 Signaling
Drugs		None	Vanucizumab Faricimab
GWAS		Blood protein levels ( 30072576 ) Body mass index ( 28552196 ) Brain morphology (MOSTest) ( 32665545 ) Corneal astigmatism ( 29422769 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Face memory ( 31596458 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) Glaucoma ( 30054594 31959993 ) Glaucoma (high intraocular pressure) ( 33627673 ) Glaucoma (primary open-angle) ( 29891935 33627673 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454 ) Male-pattern baldness ( 28196072 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (antiglaucoma preparations and miotics) ( 31015401 ) Periodontitis (stage III/IV grade C) ( 33745150 ) Periventricular white matter hyperintensities ( 32517579 ) Platelet distribution width ( 32888494 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte fraction of red cells ( 32888494 )	Alcoholic chronic pancreatitis ( 28754779 ) Blood protein levels ( 30072576 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Intraocular pressure ( 29617998 29785010 30054594 ) Metabolite levels ( 23823483 ) Response to cytidine analogues (gemcitabine) ( 24483146 )
Interacting Genes		6 interacting genes: ANGPT2 FBLN7 ITGA5 SNCA TEK TIE1	6 interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK
Entrez ID		284	285
HPRD ID		03392	03563
Ensembl ID		ENSG00000154188	ENSG00000091879
Uniprot IDs		B4DTQ9 Q15389	O15123
PDB IDs		4EPU 4JYO 4K0V	1Z3S 1Z3U 2GY7 4JZC 4ZFG 8VGP
GO Terms Enriched among Interactors		Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Tie Signaling Pathway Glomerulus Vasculature Development Angiogenesis Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Locomotion Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Blood Vessel Development Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Activity Vasculature Development Regulation Of Cell Motility Negative Regulation Of Positive Chemotaxis Response To Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Focal Adhesion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Branching Involved In Lymph Vessel Morphogenesis Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Integrin Alpha5-beta1 Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-substrate Adhesion Calcium Ion Binding Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Alphav-beta3 Integrin-vitronectin Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Proliferation Cell-substrate Adhesion Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process	Glomerulus Vasculature Development Tie Signaling Pathway Cell-substrate Adhesion Regulation Of Endothelial Cell Migration Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Vascular Permeability Angiogenesis Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Endothelial Cell Apoptotic Process Vasculature Development Regulation Of Locomotion Signaling Receptor Binding Microvillus Regulation Of Programmed Cell Death Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Endothelial Cell Migration Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Integrin Alpha5-beta1 Complex Positive Regulation Of Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Blood Vessel Development Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Endothelial Cell Proliferation Integrin Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell-substrate Adhesion Alphav-beta3 Integrin-vitronectin Complex Cellular Response To Cell-matrix Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Hemopoiesis Positive Regulation Of Angiogenesis Epithelial Cell Proliferation Positive Regulation Of Vasculature Development Positive Regulation Of Blood-brain Barrier Permeability