CCR10 and ARPC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCR10	ARPC3
Description		C-C motif chemokine receptor 10	actin related protein 2/3 complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		10 interacting genes: ARPC3 CCL19 CCL2 CCL25 CCL27 CCL28 CCL7 CCR7 CXCL13 PRRC2A	31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		2826	10094
HPRD ID		02586	09175
Ensembl ID		ENSG00000184451	ENSG00000111229
Uniprot IDs		P46092	O15145
PDB IDs			6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Chemokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Granulocyte Chemotaxis Granulocyte Migration Cell Chemotaxis Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Chemokine-mediated Signaling Pathway Locomotion Cytokine Activity Regulation Of Leukocyte Migration Chemokine Receptor Binding Humoral Immune Response Inflammatory Response CCR10 Chemokine Receptor Binding Eosinophil Chemotaxis Cell Motility Eosinophil Migration CCR Chemokine Receptor Binding Positive Regulation Of Leukocyte Chemotaxis Mononuclear Cell Migration Cell Migration Killing Of Cells Of Another Organism Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration CXCR Chemokine Receptor Binding Cell Killing Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Regulation Of Chemotaxis Response To External Biotic Stimulus Cellular Response To Lipid Defense Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Mononuclear Cell Migration CCL19-activated CCR7 Signaling Pathway Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Response To Lipopolysaccharide	Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break
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