CCR10 and CCL19

Number of citations of the paper that reports this interaction (PMID 10706668)
23

Data Source:
HPRD (in vitro)

		CCR10	CCL19
Gene Name		chemokine (C-C motif) receptor 10	chemokine (C-C motif) ligand 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Extracellular Space
	Molecular Function	G-protein Coupled Receptor Activity C-C Chemokine Receptor Activity	Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process T Cell Costimulation Positive Regulation Of Ras GTPase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Positive Regulation Of ERK1 And ERK2 Cascade Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL7 CCR7 CXCL13 PRRC2A	6 interactors: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13
Entrez ID		2826	6363
HPRD ID		02586	03750
Ensembl ID			ENSG00000172724
Uniprot IDs		P46092	Q6IBD6 Q99731
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Regulation Of Leukocyte Migration Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cell Migration Positive Regulation Of Leukocyte Migration Cell Motility Leukocyte Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Cell Migration Cellular Calcium Ion Homeostasis Positive Regulation Of Behavior Calcium Ion Homeostasis Regulation Of Cell Motility Regulation Of Chemotaxis Locomotion Regulation Of Locomotion Immune Response Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Cellular Metal Ion Homeostasis Movement Of Cell Or Subcellular Component Regulation Of Behavior Inflammatory Response Cellular Cation Homeostasis Regulation Of Dendritic Cell Dendrite Assembly Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Response To External Stimulus Negative Regulation Of Leukocyte Tethering Or Rolling Ion Homeostasis Regulation Of Cell Adhesion Regulation Of Lymphocyte Migration Immune System Process Regulation Of Granulocyte Chemotaxis Positive Regulation Of Cell Migration Establishment Of T Cell Polarity Positive Regulation Of Cell Motility Cellular Homeostasis Regulation Of Immune System Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Cell-cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemical Homeostasis Positive Regulation Of Cell-matrix Adhesion	Chemokine-mediated Signaling Pathway Chemotaxis Inflammatory Response Cytokine-mediated Signaling Pathway Locomotion Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Response To External Stimulus Immune System Process G-protein Coupled Receptor Signaling Pathway Defense Response Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis Cytosolic Calcium Ion Homeostasis Neutrophil Activation Cellular Response To Organic Substance Lymphocyte Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Response To Organic Substance Activation Of Ras GTPase Activity Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Cation Homeostasis Signal Transduction Cellular Ion Homeostasis Metal Ion Homeostasis Leukocyte Activation Signaling Positive Regulation Of Leukocyte Migration Cell Communication Cellular Chemical Homeostasis Cell Surface Receptor Signaling Pathway Ion Homeostasis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Response To Stress
Tagcloud ?		allograft allografts alloreactivity archived arrays augur cd138 cd154 cd19 cd27 existed ig iga igg igll1 immunocyte immunocytes intestine itx mucosal prone protracted reconstitution rejecting rejection repopulation serial stap1 undergoes	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?		allograft allografts alloreactivity archived arrays augur cd138 cd154 cd19 cd27 existed ig iga igg igll1 immunocyte immunocytes intestine itx mucosal prone protracted reconstitution rejecting rejection repopulation serial stap1 undergoes	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?