GNG11 and ZHX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNG11	ZHX1
Gene Name		guanine nucleotide binding protein (G protein), gamma 11	zinc fingers and homeoboxes 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Nucleus Nucleoplasm
	Molecular Function	GTPase Activity Signal Transducer Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport GPCR ligand binding beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		8 interactors: AMOTL2 CEP44 FOS GNB1 GNB4 MEOX2 SMURF1 ZHX1	50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX
Entrez ID		2791	11244
HPRD ID		11979	10379
Ensembl ID			ENSG00000165156
Uniprot IDs		P61952 Q53Y01	Q9UKY1
PDB IDs			2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Skeletal Muscle Tissue Development Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Skeletal Muscle Organ Development Tissue Development Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organonitrogen Compound Response To Transforming Growth Factor Beta Conditioned Taste Aversion Somite Specification Ubiquitin-dependent SMAD Protein Catabolic Process Cardiac Muscle Cell Apoptotic Process Response To Hormone Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Muscle Cell Apoptotic Process Muscle Organ Development Energy Derivation By Oxidation Of Organic Compounds Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Striated Muscle Tissue Development Cellular Response To Peptide Muscle Tissue Development Cellular Response To Prostaglandin E Stimulus Response To Light Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Sleep Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Gravity Segment Specification Anatomical Structure Development Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Protein Localization To Cell Surface Receptor Catabolic Process Generation Of Precursor Metabolites And Energy Organ Development Response To Immobilization Stress Response To Radiation Response To Peptide Hormone Signal Transduction Ectoderm Development Cell Surface Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Organonitrogen Compound	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		addresses aen aliquots analyzing becoming bioinformatic broader ccr4 cdkn1a chemokine concern confirmation ddb2 differentially doses enrichment forward gsea gy ionizing irradiated microarray moves pf4 ranking rays responding sets statistics	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Difference) ?		addresses aen aliquots analyzing becoming bioinformatic broader ccr4 cdkn1a chemokine concern confirmation ddb2 differentially doses enrichment forward gsea gy ionizing irradiated microarray moves pf4 ranking rays responding sets statistics	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Intersection) ?