GNG11 and AMOTL2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNG11	AMOTL2
Gene Name		guanine nucleotide binding protein (G protein), gamma 11	angiomotin like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Cytosol Tight Junction Apical Plasma Membrane Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	GTPase Activity Signal Transducer Activity	Protein Binding Identical Protein Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Wnt Signaling Pathway Hippo Signaling
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport GPCR ligand binding beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by Hippo
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		8 interactors: AMOTL2 CEP44 FOS GNB1 GNB4 MEOX2 SMURF1 ZHX1	52 interactors: BLZF1 BRMS1L CARD9 CCHCR1 CDR2 CYTH4 DDIT3 DYNLL1 EIF4E2 FAM184A FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MPP1 MTMR6 MYO5B NDC80 NFIL3 PSMC3 RAD51D RALBP1 RASSF5 RNF20 RNF40 SH3RF2 SMARCE1 SP100 SPAG5 SPP1 THRA TMCC2 TRAF2 TRIM27 WDYHV1 ZBED1 ZGPAT
Entrez ID		2791	51421
HPRD ID		11979	16485
Ensembl ID			ENSG00000114019
Uniprot IDs		P61952 Q53Y01	Q9Y2J4
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Skeletal Muscle Tissue Development Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Skeletal Muscle Organ Development Tissue Development Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organonitrogen Compound Response To Transforming Growth Factor Beta Conditioned Taste Aversion Somite Specification Ubiquitin-dependent SMAD Protein Catabolic Process Cardiac Muscle Cell Apoptotic Process Response To Hormone Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Muscle Cell Apoptotic Process Muscle Organ Development Energy Derivation By Oxidation Of Organic Compounds Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Striated Muscle Tissue Development Cellular Response To Peptide Muscle Tissue Development Cellular Response To Prostaglandin E Stimulus Response To Light Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Sleep Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Gravity Segment Specification Anatomical Structure Development Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Protein Localization To Cell Surface Receptor Catabolic Process Generation Of Precursor Metabolites And Energy Organ Development Response To Immobilization Stress Response To Radiation Response To Peptide Hormone Signal Transduction Ectoderm Development Cell Surface Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Organonitrogen Compound	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization Histone H2B Ubiquitination Regulation Of Cellular Localization Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Mitotic Cell Cycle Organelle Organization Chromosome Organization Protein Ubiquitination Histone Monoubiquitination Negative Regulation Of Viral Transcription Cell Cycle Negative Regulation Of Transcription, DNA-templated Protein Modification By Small Protein Conjugation Regulation Of Establishment Of Protein Localization Protein K63-linked Ubiquitination Histone Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter Protein Trimerization Negative Regulation Of Determination Of Dorsal Identity Regulation Of Metaphase Plate Congression Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Response To Glucagon Stimulus
Tagcloud ?		addresses aen aliquots analyzing becoming bioinformatic broader ccr4 cdkn1a chemokine concern confirmation ddb2 differentially doses enrichment forward gsea gy ionizing irradiated microarray moves pf4 ranking rays responding sets statistics	actin alanine amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap
Tagcloud (Difference) ?		addresses aen aliquots analyzing becoming bioinformatic broader ccr4 cdkn1a chemokine concern confirmation ddb2 differentially doses enrichment forward gsea gy ionizing irradiated microarray moves pf4 ranking rays responding sets statistics	actin alanine amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap
Tagcloud (Intersection) ?