GNA12 and TSHR

Number of citations of the paper that reports this interaction (PubMedID 8552586)
37

Data Source:
HPRD (in vitro)

		GNA12	TSHR
Description		G protein subunit alpha 12	thyroid stimulating hormone receptor
Image
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Lateral Plasma Membrane Brush Border Membrane Neuron Projection Neuronal Cell Body	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding Protein Phosphatase 2A Binding Protein Phosphatase Activator Activity	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Regulation Of Cell Shape Response To Xenobiotic Stimulus Regulation Of Fibroblast Migration Cell Differentiation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Embryonic Digit Morphogenesis Rho-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Thyrotropin alfa
Diseases			Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Height ( 19343178 31562340 28552196 20189936 20881960 18391951 25282103 25429064) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Medial thalamic nuclei volume ( 34006833) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Subcortical volume (MOSTest) ( 32665545) Tonsillectomy ( 28928442 27182965) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Weight ( 28552196) White matter integrity ( 23218918)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		30 interacting genes: ACTB AGTR1 AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB
Entrez ID		2768	7253
HPRD ID		05093	04537
Ensembl ID		ENSG00000146535	ENSG00000165409
Uniprot IDs		E9PC54 Q03113 Q6ZQV4	P16473
PDB IDs		7YDJ	2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7
Enriched GO Terms of Interacting Partners?		Plasma Membrane G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Membrane Regulation Of Intracellular Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of Transport Positive Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Junction Organization Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Regulation Of Protein Localization Adherens Junction Organization Cell-cell Junction Assembly Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Establishment Of Protein Localization Presynapse G Protein-coupled Receptor Activity Histone H3T6 Kinase Activity Cellular Response To Catecholamine Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Rho Protein Signal Transduction Response To Catecholamine Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Transport Positive Regulation Of Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of Protein Localization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Blood Pressure Cell Junction Organization Regulation Of MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Intracellular Signal Transduction Catenin Complex Extracellular Exosome Regulation Of Superoxide Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid	G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?