GNA12 and TSHR

Number of citations of the paper that reports this interaction (PMID 8552586)
25

Data Source:
HPRD (in vitro)

		GNA12	TSHR
Gene Name		guanine nucleotide binding protein (G protein) alpha 12	thyroid stimulating hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Brush Border Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Thyroid-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	In Utero Embryonic Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling G alpha (12/13) signalling events Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Thyrotropin Alfa
Diseases
GWAS		Height ( 20881960 19343178 18391951 20189936) Ulcerative colitis ( 23128233 21297633) White matter integrity ( 23218918)	Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		30 interactors: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 RHOA S1PR4 S1PR5 TBXA2R TEC TSHR	24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC
Entrez ID		2768	7253
HPRD ID		05093	04537
Ensembl ID		ENSG00000146535	ENSG00000165409
Uniprot IDs		B3KXS2 E9PC54 Q03113 Q6ZQV4	F5GYU5 P16473
PDB IDs			1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?		Platelet Activation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Cellular Response To Stimulus Cellular Calcium Ion Homeostasis Blood Coagulation Regulation Of Body Fluid Levels Calcium Ion Homeostasis Hemostasis Response To Organic Substance Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Metal Ion Homeostasis Apoptotic Process Programmed Cell Death Cellular Cation Homeostasis Cellular Ion Homeostasis Cell Death Death Metal Ion Homeostasis Regulation Of Signaling Chemical Homeostasis Response To Stimulus Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Homeostatic Process Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Cellular Homeostasis Neurotrophin TRK Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To External Stimulus Neurotrophin Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance
Tagcloud ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Difference) ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Intersection) ?